methyl 4-(5-chloro-2-hydroxybenzamido)-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylate

Base Information

Chemical Name:methyl 4-(5-chloro-2-hydroxybenzamido)-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylate
CAS No.:1273312-70-1
Molecular Formula:C₂₀H₁₄ClF₂NO₄S
Molecular Weight:437.851
Hs Code.:

Synonyms:methyl 4-(5-chloro-2-hydroxybenzamido)-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylate

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Chemical Property of methyl 4-(5-chloro-2-hydroxybenzamido)-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylate

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Technology Process of methyl 4-(5-chloro-2-hydroxybenzamido)-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylate

There total 6 articles about methyl 4-(5-chloro-2-hydroxybenzamido)-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1273312-65-4
methyl 4-(5-chloro-2-methoxybenzamido)-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylate

: 1273312-70-1
methyl 4-(5-chloro-2-hydroxybenzamido)-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylate

Guidance literature:: With boron tribromide; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

Reference yield:

: 245536-50-9
2,3-difluoro-4-methyl-benzaldehyde

: 1273312-70-1
methyl 4-(5-chloro-2-hydroxybenzamido)-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: morpholine / benzene; aecetic acid / Reflux

2: sodium sulfide / methanol / 1 h / 20 °C

3: hydroxylamine hydrochloride / acetonitrile; methanol / 2.5 h / 80 °C

4: phosphorus trichloride / chlorobenzene / 1.5 h / 20 - 130 °C / Inert atmosphere

5: boron tribromide / dichloromethane / 1 h / -78 °C / Inert atmosphere

With morpholine; sodium sulfide; hydroxylamine hydrochloride; boron tribromide; phosphorus trichloride; In methanol; dichloromethane; aecetic acid; chlorobenzene; acetonitrile; benzene;

Reference yield:

: 1273312-17-6
Methyl 2-(2,3-difluoro-4-methylphenyl)-4-oxotetrahydrothiophene-3-carboxylate

: 1273312-70-1
methyl 4-(5-chloro-2-hydroxybenzamido)-2-(2,3-difluoro-4-methylphenyl)thiophene-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride / acetonitrile; methanol / 2.5 h / 80 °C

2: phosphorus trichloride / chlorobenzene / 1.5 h / 20 - 130 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 1 h / -78 °C / Inert atmosphere

With hydroxylamine hydrochloride; boron tribromide; phosphorus trichloride; In methanol; dichloromethane; chlorobenzene; acetonitrile;