5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidinylsulfamido-(3'(N)->5'(N))-5'-deoxythymidine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidinylsulfamido-(3'(N)->5'(N))-5'-deoxythymidine
CAS No.:193894-21-2
Molecular Formula:C₄₁H₄₆N₆O₁₂S
Molecular Weight:846.915
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidinylsulfamido-(3'(N)->5'(N))-5'-deoxythymidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidinylsulfamido-(3'(N)->5'(N))-5'-deoxythymidine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidinylsulfamido-(3'(N)->5'(N))-5'-deoxythymidine

There total 12 articles about 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidinylsulfamido-(3'(N)->5'(N))-5'-deoxythymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 193894-17-6
5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidin-3'-ylsulfamido-[3'(N)->5'(N)]-3'-O-(tert-butyldimethylsilyl)-5'-deoxythymidine

: 193894-21-2
5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidinylsulfamido-(3'(N)->5'(N))-5'-deoxythymidine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 2h; Ambient temperature;
DOI:10.1016/S0040-4020(97)10421-5

Reference yield:

: 143526-94-7,139063-29-9
3'-amino-5'-(4,4'-dimethoxytrityl)-3'-deoxythymidine

: 193894-21-2
5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidinylsulfamido-(3'(N)->5'(N))-5'-deoxythymidine

Guidance literature:: Multi-step reaction with 3 steps

1: NEt₃; 4-nitrophenol / CH₂Cl₂

2: NEt₃; molecular sieves 4 Angstroem / CH₂Cl₂ / 20 °C

3: TBAF / tetrahydrofuran

With 4-nitro-phenol; 4 A molecular sieve; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane; 1: Substitution / 2: Substitution / 3: Desilylation;
DOI:10.1039/b001586p