4-nitrophenyl 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidine-3'-sulfamate

Base Information

Chemical Name:4-nitrophenyl 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidine-3'-sulfamate
CAS No.:288391-04-8
Molecular Formula:C₃₇H₃₆N₄O₁₁S
Molecular Weight:744.779
Hs Code.:

Synonyms:4-nitrophenyl 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidine-3'-sulfamate

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Chemical Property of 4-nitrophenyl 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidine-3'-sulfamate

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Technology Process of 4-nitrophenyl 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidine-3'-sulfamate

There total 3 articles about 4-nitrophenyl 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidine-3'-sulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 18997-12-1
4-nitrophenyl sulfurochloridate

: 143526-94-7,139063-29-9
3'-amino-5'-(4,4'-dimethoxytrityl)-3'-deoxythymidine

: 288391-04-8
4-nitrophenyl 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidine-3'-sulfamate

Guidance literature:: With 4-nitro-phenol; triethylamine; In dichloromethane; at -78 ℃; for 0.5h;
DOI:10.1039/b110603c

Reference yield: 58.0%

: 18997-12-1
4-nitrophenyl sulfurochloridate

: 143526-94-7,139063-29-9
3'-amino-5'-(4,4'-dimethoxytrityl)-3'-deoxythymidine

: 288391-04-8
4-nitrophenyl 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidine-3'-sulfamate

: C₆₂H₆₄N₆O₁₄S

Guidance literature:: In dichloromethane; at -78 ℃; for 0.5h;
DOI:10.1039/b110603c

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 288391-04-8
4-nitrophenyl 5'-O-(4,4'-dimethoxytrityl)-3'-deoxythymidine-3'-sulfamate

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / pyridine; SO₂Cl₂ / diethyl ether / 4 h / 20 °C

2: 68 percent / 4-nitrophenol; Et₃N / CH₂Cl₂ / 0.5 h / -78 °C

With pyridine; sulfuryl dichloride; 4-nitro-phenol; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1039/b110603c