Ν-(2-(2-(9-(tetrahydro-2-hydro-pyran-2-yl)-9H-purin-6-yl)phenylamino)-4-pyridyl)propane-1-sulfonamide

Base Information

Chemical Name:Ν-(2-(2-(9-(tetrahydro-2-hydro-pyran-2-yl)-9H-purin-6-yl)phenylamino)-4-pyridyl)propane-1-sulfonamide
CAS No.:1437316-94-3
Molecular Formula:C₂₄H₂₇N₇O₃S
Molecular Weight:493.589
Hs Code.:

Synonyms:Ν-(2-(2-(9-(tetrahydro-2-hydro-pyran-2-yl)-9H-purin-6-yl)phenylamino)-4-pyridyl)propane-1-sulfonamide

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Chemical Property of Ν-(2-(2-(9-(tetrahydro-2-hydro-pyran-2-yl)-9H-purin-6-yl)phenylamino)-4-pyridyl)propane-1-sulfonamide

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Technology Process of Ν-(2-(2-(9-(tetrahydro-2-hydro-pyran-2-yl)-9H-purin-6-yl)phenylamino)-4-pyridyl)propane-1-sulfonamide

There total 8 articles about Ν-(2-(2-(9-(tetrahydro-2-hydro-pyran-2-yl)-9H-purin-6-yl)phenylamino)-4-pyridyl)propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1437316-89-6
2-(9-(tetrahydro-2-hydropyran-2-yl)-9H-purin-6-yl)aniline

: 1437316-93-2
Ν-(2-chloropyridin-4-yl)propane-1-sulfonamide

: 1437316-94-3
Ν-(2-(2-(9-(tetrahydro-2-hydro-pyran-2-yl)-9H-purin-6-yl)phenylamino)-4-pyridyl)propane-1-sulfonamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In toluene; at 170 ℃; for 2h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 615-36-1
2-bromoaniline

: 1437316-94-3
Ν-(2-(2-(9-(tetrahydro-2-hydro-pyran-2-yl)-9H-purin-6-yl)phenylamino)-4-pyridyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 15 h / 80 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; acetonitrile / 0.25 h / 170 °C / Inert atmosphere; Microwave irradiation

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / toluene / 2 h / 170 °C / Inert atmosphere; Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In 1,4-dioxane; water; toluene; acetonitrile;

Reference yield:

: 14432-12-3
4-Amino-2-chloropyridine

: 1437316-94-3
Ν-(2-(2-(9-(tetrahydro-2-hydro-pyran-2-yl)-9H-purin-6-yl)phenylamino)-4-pyridyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 1,2-dichloro-ethane / 20 h / Reflux

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / toluene / 2 h / 170 °C / Inert atmosphere; Microwave irradiation

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In 1,2-dichloro-ethane; toluene;