[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-amine

Base Information

• Chemical Name: [3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-amine
• CAS No.: 405551-85-1
• Molecular Formula: C₃₈H₃₅ClN₄
• Molecular Weight: 583.176

Synonyms:[3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-amine

Chemical Property of [3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-amine

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Technology Process of [3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-amine

There total 4 articles about [3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(4-chloro-phenyl)-3-pyridin-2-yl-N-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-propionamide (405551-77-1) → [3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-amine (405551-85-1)

Guidance literature:

With boron dimethyl-trifluoro sulphide; In tetrahydrofuran;

DOI:10.1016/S0960-894X(03)00357-3

Reference yield:

2-(4-chlorobenzoyl)pyridine (6318-51-0) → [3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-amine (405551-85-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / NaH / tetrahydrofuran

2: 45 percent / Mg; MeOH

3: Me₃Al / toluene

4: 100 percent / BF₃*Me₂S / tetrahydrofuran

With methanol; boron dimethyl-trifluoro sulphide; trimethylaluminum; sodium hydride; magnesium; In tetrahydrofuran; toluene; 1: Wittig olefination;

DOI:10.1016/S0960-894X(03)00357-3

Reference yield:

(E)-3-(4-Chloro-phenyl)-3-pyridin-2-yl-acrylic acid methyl ester (405551-66-8) → [3-(4-chloro-phenyl)-3-pyridin-2-yl-propyl]-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-amine (405551-85-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 45 percent / Mg; MeOH

2: Me₃Al / toluene

3: 100 percent / BF₃*Me₂S / tetrahydrofuran

With methanol; boron dimethyl-trifluoro sulphide; trimethylaluminum; magnesium; In tetrahydrofuran; toluene;

DOI:10.1016/S0960-894X(03)00357-3

upstream raw materials:

3-(4-chloro-phenyl)-3-pyridin-2-yl-N-[2-(1-trityl-1H-imidazol-4-yl)-ethyl]-propionamide

2-(4-chlorobenzoyl)pyridine

(E)-3-(4-Chloro-phenyl)-3-pyridin-2-yl-acrylic acid methyl ester

3-(4-chloro-phenyl)-3-pyridin-2-yl-propionic acid methyl ester

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