6318-51-0

Basic information

• Product Name: (4-chlorophenyl) 2-pyridyl ketone
• Synonyms: (4-Chlorophenyl)(2-pyridinyl)methanone;Einecs 228-662-8;4-chlorophenyl-2-pyridylmethanon;(4-chlorophenyl)(pyridin-2-yl)methanone(SALTDATA: FREE);(4-chlorophenyl)-pyridin-2-ylMethanone;(4-chlorophenyl) 2-pyridyl ketone
• CAS NO: 6318-51-0
• Molecular Formula: C₁₂H₈ClNO
• Molecular Weight: 217.65102
• EINECS: 228-662-8
• Mol File: 6318-51-0.mol
• Article Data: 38

Chemical Properties

• Melting Point: 62.0 to 66.0 °C
• Boiling Point: 160°C/0.6mmHg(lit.)
• Flash Point: 169.1 °C
• Appearance: /
• Density: 1.26 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble in Methanol
• PKA: 2.69±0.10(Predicted)
• CAS DataBase Reference: (4-chlorophenyl) 2-pyridyl ketone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-chlorophenyl) 2-pyridyl ketone(6318-51-0)
• EPA Substance Registry System: (4-chlorophenyl) 2-pyridyl ketone(6318-51-0)

Safety Data

• Hazardous Substances Data: 6318-51-0(Hazardous Substances Data)

Usage

Uses

2-(4-Chlorobenzoyl)pyridine can be used as reactant/reagent in asymmetric transfer hydrogenation of aryl N-heteroaryl ketones catalyzed bifunctional oxo-tethered ruthenium complex.

InChI:InChI=1/C12H8ClNO/c13-10-6-4-9(5-7-10)12(15)11-3-1-2-8-14-11/h1-8H

Upstream product

• 29745-44-6 pyridine-2-carbonyl chloride 
• 108-90-7 chlorobenzene 
• 4350-41-8 2-(4-chlorobenzyl)pyridine 
• 5005-37-8 2-(4-chlorophenyl)-2-(pyridin-2-yl)acetonitrile 
• 110-86-1 pyridine 
• 122-01-0 4-chloro-benzoyl chloride 
• 17624-36-1 2-pyridyllithium 
• 109-04-6 2-bromo-pyridine 
• 101-82-6 2-Benzylpyridine 
• 20482-10-4 2-(4-chlorobenzyl)pyridine 1-oxide 
• 5029-67-4 2-iodopyridine 
• 64-18-6 formic acid 
• 1679-18-1 4-Chlorophenylboronic acid 
• 694-59-7 pyridine N-oxide 

Downstream Products

• 14017-85-7 2-[2-(4-chloro-phenyl)-5,5-dimethyl-[1,3]dioxan-2-yl]-pyridine 
• 21674-81-7 2-[2-(4-chloro-phenyl)-tetrahydro-furan-2-yl]-pyridine 
• 861902-65-0 1-(4-chlorophenyl)-3-methyl-1-(pyridin-2-yl)-1-butanol 
• 107776-02-3 1-(4-chlorophenyl)-1-(2-pyridyl)-1-propanol 
• 861902-64-9 1-(4-chlorophenyl)-1-(2-pyridyl)-1-butanol 
• 62946-37-6 2-chloro-5-(2-pyridinecarbonyl)-nitrobenzene 
• 78539-96-5 2-[(4-chlorophenyl)(hydrazono)methyl]pyridine 
• 78539-93-2 3-(4-chlorophenyl)-[1,2,3]triazolo[1,5-a]pyridine 
• 27693-35-2 2,4-dichlorophenyl(pyridin-2-yl)methanone 
• 1261559-44-7 2-bromo-4-chlorophenyl(pyridin-2-yl)methanone 
• 861902-68-3 2-[2-(4-chlorophenyl)-3-ethyloxiranyl]pyridine 

Relevant articles and documents

Overcoming Electron-Withdrawing and Product-Inhibition Effects by Organocatalytic Aerobic Oxidation of Alkylpyridines and Related Alkylheteroarenes to Ketones

An organocatalyzed aerobic benzylic C-H oxidation of alkyl and aryl heterocycles has been developed. This transition metal-free method is able to overcome the electron-withdrawing effect as well as product-inhibition effects in heterobenzylic radical oxidation. A variety of ketones bearing N-heterocyclic groups could be prepared under relatively mild conditions with moderate to high yields.

Iron-catalyzed oxidative functionalization of C(sp3)-H bonds under bromide-synergized mild conditions

An efficient oxidation and functionalization of C-H bonds with an inorganic-ligand supported iron catalyst and hydrogen peroxide to prepare the corresponding ketones was achieved using the bromide ion as a promoter. Preliminary mechanistic investigations indicated that the bromide ion can bind to FeMo6 to form a supramolecular species (FeMo6·2Br), which can effectively catalyze the reaction.

A convenient and practical heterogeneous palladium-catalyzed carbonylative Suzuki coupling of aryl iodides with formic acid as carbon monoxide source

A practical heterogeneous palladium-catalyzed carbonylative Suzuki coupling of aryl iodides with arylboronic acids under carbon monoxide gas-free conditions has been developed using a bidentate phosphino-functionalized magnetic nanoparticle-immobilized palladium(II) complex as catalyst. Formic acid was utilized as the carbon monoxide source with dicyclohexylcarbodiimide as the activator, and a wide variety of biaryl ketones were generated in moderate to high yields. The new heterogeneous palladium catalyst can be prepared via a simple procedure and can easily be separated from a reaction mixture by simply applying an external magnet and recycled up to 10 times without any loss of activity.