Technology Process of 5-azido-3,6-di-O-benzyl-5-deoxy-L-gulono-1,4-lactone
There total 7 articles about 5-azido-3,6-di-O-benzyl-5-deoxy-L-gulono-1,4-lactone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-azido-3,6-di-O-benzyl-5-deoxy-2-O-trifluoromethanesulfonyl-L-idono-1,4-lactone;
With
sodium 2,2,2-trifluoroacetate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
Inert atmosphere;
With
water; sodium hydrogencarbonate;
In
ethyl acetate;
DOI:10.1021/jo301243s
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 17 h / -10 - 20 °C / Inert atmosphere
2: toluene-4-sulfonic acid / water; 1,4-dioxane / 2.5 h / 80 °C
3: iodine; potassium carbonate / tert-butyl alcohol / 2 h / 100 °C
4: pyridine / dichloromethane / 1 h / -40 °C / Inert atmosphere
5: sodium 2,2,2-trifluoroacetate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
With
pyridine; iodine; sodium 2,2,2-trifluoroacetate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid;
In
1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;
DOI:10.1021/jo301243s
- Guidance literature:
-
Multi-step reaction with 4 steps
1: toluene-4-sulfonic acid / water; 1,4-dioxane / 2.5 h / 80 °C
2: iodine; potassium carbonate / tert-butyl alcohol / 2 h / 100 °C
3: pyridine / dichloromethane / 1 h / -40 °C / Inert atmosphere
4: sodium 2,2,2-trifluoroacetate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere
With
pyridine; iodine; sodium 2,2,2-trifluoroacetate; potassium carbonate; toluene-4-sulfonic acid;
In
1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jo301243s
