(R)-cyclohexyl(phenyl)[1-(piperidin-4-ylmethyl)-1H-1,2,4-triazol-3-yl]methanol

Base Information

Chemical Name:(R)-cyclohexyl(phenyl)[1-(piperidin-4-ylmethyl)-1H-1,2,4-triazol-3-yl]methanol
CAS No.:1204122-44-0
Molecular Formula:C₂₁H₃₀N₄O
Molecular Weight:354.495
Hs Code.:

Synonyms:(R)-cyclohexyl(phenyl)[1-(piperidin-4-ylmethyl)-1H-1,2,4-triazol-3-yl]methanol

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Chemical Property of (R)-cyclohexyl(phenyl)[1-(piperidin-4-ylmethyl)-1H-1,2,4-triazol-3-yl]methanol

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Technology Process of (R)-cyclohexyl(phenyl)[1-(piperidin-4-ylmethyl)-1H-1,2,4-triazol-3-yl]methanol

There total 6 articles about (R)-cyclohexyl(phenyl)[1-(piperidin-4-ylmethyl)-1H-1,2,4-triazol-3-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1204122-42-8
tert-butyl 4-({3-[(R)-cyclohexyl(hydroxy)phenylmethy]-1H-1,2,4-triazol-1-yl}methyl)piperidine-1-carboxylate

: 1204122-44-0
(R)-cyclohexyl(phenyl)[1-(piperidin-4-ylmethyl)-1H-1,2,4-triazol-3-yl]methanol

Guidance literature:: tert-butyl 4-({3-[(R)-cyclohexyl(hydroxy)phenylmethy]-1H-1,2,4-triazol-1-yl}methyl)piperidine-1-carboxylate; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 24h;

With sodium hydrogencarbonate; In dichloromethane; water; Product distribution / selectivity;

Reference yield:

: 1204122-40-6
(R)-cyclohexyl(phenyl)1H-1,2,4-triazol-3-ylmethanol

: 1204122-44-0
(R)-cyclohexyl(phenyl)[1-(piperidin-4-ylmethyl)-1H-1,2,4-triazol-3-yl]methanol

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / acetone / 5 h / 70 °C

2: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

With hydrogenchloride; caesium carbonate; In 1,4-dioxane; acetone;
DOI:10.1016/j.bmcl.2015.10.008

Reference yield:

: 1204122-37-1
(2R)-2-cyclohexyl-2-hydroxy-2-phenylacetamide

: 1204122-44-0
(R)-cyclohexyl(phenyl)[1-(piperidin-4-ylmethyl)-1H-1,2,4-triazol-3-yl]methanol

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 2 h / 90 °C

2: hydrazine hydrate; acetic acid / toluene / 2 h / 90 °C

3: caesium carbonate / acetone / 5 h / 70 °C

4: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

With hydrogenchloride; caesium carbonate; hydrazine hydrate; acetic acid; In 1,4-dioxane; acetone; toluene;
DOI:10.1016/j.bmcl.2015.10.008