(R)-{1-[(1-{2-[4-(2-aminoethyl)phenyl]ethyl}piperidin-4-yl)methyl]-1H-1,2,4-triazol-3-yl}(cyclohexyl)phenylmethanol

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Chemical Name:(R)-{1-[(1-{2-[4-(2-aminoethyl)phenyl]ethyl}piperidin-4-yl)methyl]-1H-1,2,4-triazol-3-yl}(cyclohexyl)phenylmethanol
CAS No.:1204122-67-7
Molecular Formula:C₃₁H₄₃N₅O
Molecular Weight:501.715
Hs Code.:

Synonyms:(R)-{1-[(1-{2-[4-(2-aminoethyl)phenyl]ethyl}piperidin-4-yl)methyl]-1H-1,2,4-triazol-3-yl}(cyclohexyl)phenylmethanol

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Chemical Property of (R)-{1-[(1-{2-[4-(2-aminoethyl)phenyl]ethyl}piperidin-4-yl)methyl]-1H-1,2,4-triazol-3-yl}(cyclohexyl)phenylmethanol

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Technology Process of (R)-{1-[(1-{2-[4-(2-aminoethyl)phenyl]ethyl}piperidin-4-yl)methyl]-1H-1,2,4-triazol-3-yl}(cyclohexyl)phenylmethanol

There total 8 articles about (R)-{1-[(1-{2-[4-(2-aminoethyl)phenyl]ethyl}piperidin-4-yl)methyl]-1H-1,2,4-triazol-3-yl}(cyclohexyl)phenylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1204122-61-1
2-[2-(4-{2-[4-({3-[(R)-cyclohexyl(hydroxy)phenylmethyl]-1H-1,2,4-triazol-1-yl}methyl)piperdin-1-yl]ethyl}phenyl)ethyl]-1H-isoindole-1,3(2H)-dione

: 1204122-67-7
(R)-{1-[(1-{2-[4-(2-aminoethyl)phenyl]ethyl}piperidin-4-yl)methyl]-1H-1,2,4-triazol-3-yl}(cyclohexyl)phenylmethanol

Guidance literature:: With hydrazine hydrate; In ethanol; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2015.10.008

Reference yield:

: 1204122-44-0
(R)-cyclohexyl(phenyl)[1-(piperidin-4-ylmethyl)-1H-1,2,4-triazol-3-yl]methanol

: 1204122-67-7
(R)-{1-[(1-{2-[4-(2-aminoethyl)phenyl]ethyl}piperidin-4-yl)methyl]-1H-1,2,4-triazol-3-yl}(cyclohexyl)phenylmethanol

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / butanone / 24 h / 90 °C

2: hydrazine hydrate / ethanol / 1 h / 20 °C

With hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In ethanol; butanone;
DOI:10.1016/j.bmcl.2015.10.008

Reference yield:

: 1204122-40-6
(R)-cyclohexyl(phenyl)1H-1,2,4-triazol-3-ylmethanol

: 1204122-67-7
(R)-{1-[(1-{2-[4-(2-aminoethyl)phenyl]ethyl}piperidin-4-yl)methyl]-1H-1,2,4-triazol-3-yl}(cyclohexyl)phenylmethanol

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / acetone / 5 h / 70 °C

2: hydrogenchloride / 1,4-dioxane / 24 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / butanone / 24 h / 90 °C

4: hydrazine hydrate / ethanol / 1 h / 20 °C

With hydrogenchloride; caesium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; ethanol; acetone; butanone;
DOI:10.1016/j.bmcl.2015.10.008