Thiocarbonic acid O-((7R,8R)-2-chloro-8-phenyl-5,6,7,8-tetrahydro-quinolin-7-yl) ester O-phenyl ester

Base Information

Chemical Name:Thiocarbonic acid O-((7R,8R)-2-chloro-8-phenyl-5,6,7,8-tetrahydro-quinolin-7-yl) ester O-phenyl ester
CAS No.:175410-78-3
Molecular Formula:C₂₂H₁₈ClNO₂S
Molecular Weight:395.909
Hs Code.:

Synonyms:Thiocarbonic acid O-((7R,8R)-2-chloro-8-phenyl-5,6,7,8-tetrahydro-quinolin-7-yl) ester O-phenyl ester

Suppliers and Price of Thiocarbonic acid O-((7R,8R)-2-chloro-8-phenyl-5,6,7,8-tetrahydro-quinolin-7-yl) ester O-phenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Thiocarbonic acid O-((7R,8R)-2-chloro-8-phenyl-5,6,7,8-tetrahydro-quinolin-7-yl) ester O-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Thiocarbonic acid O-((7R,8R)-2-chloro-8-phenyl-5,6,7,8-tetrahydro-quinolin-7-yl) ester O-phenyl ester

There total 4 articles about Thiocarbonic acid O-((7R,8R)-2-chloro-8-phenyl-5,6,7,8-tetrahydro-quinolin-7-yl) ester O-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 175410-66-9
(7R,8R)-2-chloro-7-hydroxy-8-phenyl-5,6,7,8-tetrahydroquinoline

: 1005-56-7
phenylcarbonochloridothioate

: 175410-78-3
Thiocarbonic acid O-((7R,8R)-2-chloro-8-phenyl-5,6,7,8-tetrahydro-quinolin-7-yl) ester O-phenyl ester

Guidance literature:: With dmap; In acetonitrile; for 3h; Ambient temperature;
DOI:10.1016/S0040-4020(96)00058-0

Reference yield:

: 21172-88-3
2-chloro-5,6,7,8-tetrahydro-quinoline

: 175410-78-3
Thiocarbonic acid O-((7R,8R)-2-chloro-8-phenyl-5,6,7,8-tetrahydro-quinolin-7-yl) ester O-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA, 2.) PhSSPh, 3.) mCPBA

2: 73 percent / 4-phenylpyridine-N-oxide, Mn-salen complex, aq. NaClO, phosphate buffer / CH₂Cl₂ / 3 h

3: 1.) CuCN, 2.) BF₃*OEt₂ / 1.) cyclohexane, ether, THF, -10 deg C, 5 min, 2.) cyclohexane, ether, THF, -78 deg C, 2 h

4: 68 percent / DMAP / acetonitrile / 3 h / Ambient temperature

With dmap; sodium hypochlorite; 4-Phenylpyridine 1-oxide; phosphate buffer; 2,2′-((1E,1′E)-(ethane-1,2-diylbis(azanylylidene))bis(methanylylidene))diphenolmanganese(II); boron trifluoride diethyl etherate; 3-chloro-benzenecarboperoxoic acid; diphenyldisulfane; lithium diisopropyl amide; In dichloromethane; acetonitrile;
DOI:10.1016/S0040-4020(96)00058-0

Reference yield:

: 2-chloro-5,6-dihydroquinoline

: 175410-78-3
Thiocarbonic acid O-((7R,8R)-2-chloro-8-phenyl-5,6,7,8-tetrahydro-quinolin-7-yl) ester O-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / 4-phenylpyridine-N-oxide, Mn-salen complex, aq. NaClO, phosphate buffer / CH₂Cl₂ / 3 h

2: 1.) CuCN, 2.) BF₃*OEt₂ / 1.) cyclohexane, ether, THF, -10 deg C, 5 min, 2.) cyclohexane, ether, THF, -78 deg C, 2 h

3: 68 percent / DMAP / acetonitrile / 3 h / Ambient temperature

With dmap; sodium hypochlorite; 4-Phenylpyridine 1-oxide; phosphate buffer; 2,2′-((1E,1′E)-(ethane-1,2-diylbis(azanylylidene))bis(methanylylidene))diphenolmanganese(II); boron trifluoride diethyl etherate; In dichloromethane; acetonitrile;
DOI:10.1016/S0040-4020(96)00058-0