21172-88-3 Usage
Uses
Used in Pharmaceutical and Agrochemical Synthesis:
2-chloro-5,6,7,8-tetrahydroquinoline is utilized as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and reactivity allow for the development of new compounds with potential therapeutic and pesticidal properties.
Used in Dye and Fine Chemical Production:
2-chloro-5,6,7,8-tetrahydroquinoline also serves as a building block in the production of dyes and other fine chemicals. Its ability to form a variety of chemical bonds and structures makes it a valuable component in the creation of specialized dyes and other high-quality chemical products.
Used in Medicinal Chemistry Research:
2-chloro-5,6,7,8-tetrahydroquinoline has been studied for its potential use in the treatment of various diseases and conditions. Its presence in the quinoline family of compounds, which is known for its diverse range of biological activities, positions it as an important compound in the field of medicinal chemistry. Researchers are exploring its potential applications in drug discovery and development, aiming to harness its properties for therapeutic benefits.
Check Digit Verification of cas no
The CAS Registry Mumber 21172-88-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,1,7 and 2 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 21172-88:
(7*2)+(6*1)+(5*1)+(4*7)+(3*2)+(2*8)+(1*8)=83
83 % 10 = 3
So 21172-88-3 is a valid CAS Registry Number.
21172-88-3Relevant academic research and scientific papers
Zong, Zhijian,Wu, Ke,Jin, Liqun,Sun, Nan,Hu, Baoxiang,Shen, Zhenlu,Hu, Xinquan
, p. 3675 - 3683 (2020)
An efficient large-scale preparation of 2-chlorotetrahydroquinoline with cyclohexanone and benzylamine as starting materials was developed and well optimized, in which benzyl-protected enamide was successfully cyclized and benzyl group was directly removed under Vilsmeier conditions. Azeotropic distillation provided 264 g of 2-chlorotetrahydroquinoline (79%) on a 2 mol scale of reaction without intermediate isolation. The downstream product 2-chlorotetrahydroquinolin-8-one was acquired through Boekelheide rearrangement, hydrolysis of acetate via NaBH 4reduction, and Anelli oxidation. With the developed procedure, the intermediates were not necessary to be isolated and 2-chlorotetrahydroquinolin-8-one was conveniently obtained with solvent slurry in 65% overall isolated yield in a four-step sequence.
