C₂₇H₃₂BrN₃O₅

Base Information

• Chemical Name: C₂₇H₃₂BrN₃O₅
• CAS No.: 1236006-72-6
• Molecular Formula: C₂₇H₃₂BrN₃O₅
• Molecular Weight: 558.472
• Mol file: 1236006-72-6.mol

Synonyms:C₂₇H₃₂BrN₃O₅

Chemical Property of C₂₇H₃₂BrN₃O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₃₂BrN₃O₅

There total 12 articles about C₂₇H₃₂BrN₃O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H32N2O8 + m-Bromoaniline (591-19-5) → C27H32BrN3O5 (1236006-72-6)

Guidance literature:

In ethyl acetate; at 20 ℃; for 12h;

DOI:10.1016/j.ejmech.2014.07.106

Reference yield:

C21H28N2O6 (1201518-42-4) + m-Bromoaniline (591-19-5) → C27H32BrN3O5 (1236006-72-6)

Guidance literature:

With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 - 25 ℃; for 16h;

DOI:10.1016/j.bmcl.2010.04.123

Reference yield:

C12H20O3 → C27H32BrN3O5 (1236006-72-6)

Guidance literature:

Multi-step reaction with 8 steps

1.1: n-butyllithium / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: 24 h / 45 °C / Inert atmosphere

2.2: 1.5 h / Inert atmosphere

2.3: 0.5 h / Inert atmosphere

3.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 1 h / 0 °C

4.1: 20 - 60 °C

5.1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

6.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 1 h / 20 °C

7.1: tetrahydrofuran / 1 h / 0 - 20 °C

8.1: ethyl acetate / 12 h / 20 °C

With 4-methyl-morpholine; n-butyllithium; lithium hydroxide monohydrate; dihydrogen peroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water; ethyl acetate;

DOI:10.1016/j.ejmech.2014.07.106

upstream raw materials:

C₂₁H₂₈N₂O₆

m-Bromoaniline

C₂₂H₃₀N₂O₆

diethyl butylmalonate

Downstream raw materials:

(S)-1-((R)-2-((formylhydroxyamino)methyl)hexanoyl)-N-(3-bromophenyl)-2,5-dihydro-1H-pyrrole-2-carboxamide