trans-1-methyl-4-(methyloxy)cyclohexanamine monohydrochloride

Base Information

• Chemical Name: trans-1-methyl-4-(methyloxy)cyclohexanamine monohydrochloride
• CAS No.: 950773-03-2
• Molecular Formula: C₈H₁₇NO*ClH
• Molecular Weight: 179.69
• Mol file: 950773-03-2.mol

Synonyms:trans-1-methyl-4-(methyloxy)cyclohexanamine monohydrochloride

Chemical Property of trans-1-methyl-4-(methyloxy)cyclohexanamine monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-1-methyl-4-(methyloxy)cyclohexanamine monohydrochloride

There total 3 articles about trans-1-methyl-4-(methyloxy)cyclohexanamine monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

trans-1-isocyanato-1-methyl-4-(methyloxy)cyclohexane (950773-02-1) → trans-1-methyl-4-(methyloxy)cyclohexanamine monohydrochloride (950773-03-2)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃;

Reference yield:

cis/trans-1-methyl-4-(methyloxy)cyclohexanecarboxylic acid (150864-93-0) → trans-1-methyl-4-(methyloxy)cyclohexanamine monohydrochloride (950773-03-2)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / 4 h / 90 °C / Heating / reflux

2: sodium carbonate / tetrahydrofuran; hexane / 0.5 h / 20 °C

3: diphenyl phosphoryl azide; triethylamine / toluene / 2 h / 20 - 80 °C / Heating / reflux

4: hydrogenchloride / tetrahydrofuran; water / 4 h / 20 °C

With hydrogenchloride; thionyl chloride; diphenyl phosphoryl azide; sodium carbonate; triethylamine; In tetrahydrofuran; hexane; water; toluene;

Reference yield:

1-methyl-trans-4-methoxycyclohexanecarboxylic acid (73873-63-9) → trans-1-methyl-4-(methyloxy)cyclohexanamine monohydrochloride (950773-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenyl phosphoryl azide; triethylamine / toluene / 2 h / 20 - 80 °C / Heating / reflux

2: hydrogenchloride / tetrahydrofuran; water / 4 h / 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine; In tetrahydrofuran; water; toluene;

upstream raw materials:

trans-1-isocyanato-1-methyl-4-(methyloxy)cyclohexane

cis/trans-1-methyl-4-(methyloxy)cyclohexanecarboxylic acid

1-methyl-trans-4-methoxycyclohexanecarboxylic acid

Downstream raw materials:

1-[trans-1-methyl-4-(methyloxy)cyclohexyl]-4-piperidinone

1-[trans-1-methyl-4-(methyloxy)cyclohexyl]-4-piperidinamine

(2-amino-5-fluorophenyl){1-[trans-4-(methyloxy)-1-methylcyclohexyl]-4-piperidinyl}amine

N-(5-fluoro-2-nitrophenyl)-1-[trans-1-methyl-4-(methyloxy)cyclohexyl]-4-piperidinamine

Refernces

• 1、 -. "COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE". Page/Page column 89-90. . Retrieved 2009/04/25.