Technology Process of N-(5-fluoro-2-nitrophenyl)-1-[trans-1-methyl-4-(methyloxy)cyclohexyl]-4-piperidinamine
There total 8 articles about N-(5-fluoro-2-nitrophenyl)-1-[trans-1-methyl-4-(methyloxy)cyclohexyl]-4-piperidinamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 100 ℃;
for 1h;
Microwave reactor;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: acetone / 3 h / 0 - 30 °C
2: potassium carbonate / ethanol; water / 80 °C / Heating / reflux
3: ammonia; hydrogen / palladium 10% on activated carbon / methanol / 24 h / 20 °C / 2585.81 Torr
4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 100 °C / Microwave reactor
With
ammonia; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine;
palladium 10% on activated carbon;
In
methanol; ethanol; water; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: thionyl chloride / 4 h / 90 °C / Heating / reflux
2: sodium carbonate / tetrahydrofuran; hexane / 0.5 h / 20 °C
3: diphenyl phosphoryl azide; triethylamine / toluene / 2 h / 20 - 80 °C / Heating / reflux
4: hydrogenchloride / tetrahydrofuran; water / 4 h / 20 °C
5: potassium carbonate / ethanol; water / 80 °C / Heating / reflux
6: ammonia; hydrogen / palladium 10% on activated carbon / methanol / 24 h / 20 °C / 2585.81 Torr
7: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 100 °C / Microwave reactor
With
hydrogenchloride; thionyl chloride; diphenyl phosphoryl azide; ammonia; hydrogen; sodium carbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; ethanol; hexane; water; N,N-dimethyl-formamide; toluene;