5-(1H-imidazol-1-yl)-2-nitro-N-(1-benzyl-3-pyrrolidinyl)aniline

Base Information

• Chemical Name: 5-(1H-imidazol-1-yl)-2-nitro-N-(1-benzyl-3-pyrrolidinyl)aniline
• CAS No.: 181869-99-8
• Molecular Formula: C₂₀H₂₁N₅O₂
• Molecular Weight: 363.419
• Mol file: 181869-99-8.mol

Synonyms:5-(1H-imidazol-1-yl)-2-nitro-N-(1-benzyl-3-pyrrolidinyl)aniline

Chemical Property of 5-(1H-imidazol-1-yl)-2-nitro-N-(1-benzyl-3-pyrrolidinyl)aniline

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 5-(1H-imidazol-1-yl)-2-nitro-N-(1-benzyl-3-pyrrolidinyl)aniline

There total 3 articles about 5-(1H-imidazol-1-yl)-2-nitro-N-(1-benzyl-3-pyrrolidinyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1H-imidazole (288-32-4) + (1-Benzyl-pyrrolidin-3-yl)-(5-chloro-2-nitro-phenyl)-amine (1026490-44-7) → 5-(1H-imidazol-1-yl)-2-nitro-N-(1-benzyl-3-pyrrolidinyl)aniline (181869-99-8)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 120 ℃; for 2h; Yield given;

DOI:10.1021/jm960387+

Reference yield:

4-chloro-2-fluoro-nitrobenzene (700-37-8) → 5-(1H-imidazol-1-yl)-2-nitro-N-(1-benzyl-3-pyrrolidinyl)aniline (181869-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 1 h

2: KOH / dimethylsulfoxide / 2 h / 120 °C

With potassium hydroxide; In ethanol; dimethyl sulfoxide;

DOI:10.1021/jm960387+

Reference yield:

1-Benzyl-3-aminopyrrolidine (18471-40-4,60652-45-1,114715-38-7,114715-39-8) → 5-(1H-imidazol-1-yl)-2-nitro-N-(1-benzyl-3-pyrrolidinyl)aniline (181869-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 1 h

2: KOH / dimethylsulfoxide / 2 h / 120 °C

With potassium hydroxide; In ethanol; dimethyl sulfoxide;

DOI:10.1021/jm960387+

upstream raw materials:

1H-imidazole

(1-Benzyl-pyrrolidin-3-yl)-(5-chloro-2-nitro-phenyl)-amine

4-chloro-2-fluoro-nitrobenzene

1-Benzyl-3-aminopyrrolidine