(1-Benzyl-pyrrolidin-3-yl)-(5-chloro-2-nitro-phenyl)-amine

Base Information

• Chemical Name: (1-Benzyl-pyrrolidin-3-yl)-(5-chloro-2-nitro-phenyl)-amine
• CAS No.: 1026490-44-7
• Molecular Formula: C₁₇H₁₈ClN₃O₂
• Molecular Weight: 331.802
• Mol file: 1026490-44-7.mol

Synonyms:(1-Benzyl-pyrrolidin-3-yl)-(5-chloro-2-nitro-phenyl)-amine

Chemical Property of (1-Benzyl-pyrrolidin-3-yl)-(5-chloro-2-nitro-phenyl)-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-Benzyl-pyrrolidin-3-yl)-(5-chloro-2-nitro-phenyl)-amine

There total 1 articles about (1-Benzyl-pyrrolidin-3-yl)-(5-chloro-2-nitro-phenyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-2-fluoro-nitrobenzene (700-37-8) + 1-Benzyl-3-aminopyrrolidine (18471-40-4,60652-45-1,114715-38-7,114715-39-8) → (1-Benzyl-pyrrolidin-3-yl)-(5-chloro-2-nitro-phenyl)-amine (1026490-44-7)

Guidance literature:

In ethanol; for 1h;

DOI:10.1021/jm960387+

Reference yield:

(1-Benzyl-pyrrolidin-3-yl)-(5-chloro-2-nitro-phenyl)-amine (1026490-44-7) → 4-Imidazol-1-yl-N2-pyrrolidin-3-yl-benzene-1,2-diamine

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / dimethylsulfoxide / 2 h / 120 °C

2: H₂, conc. HCl / 10percent Pd/C / methanol / 760 Torr

With hydrogenchloride; potassium hydroxide; hydrogen; palladium on activated charcoal; In methanol; dimethyl sulfoxide;

DOI:10.1021/jm960387+

Reference yield:

1H-imidazole (288-32-4) + (1-Benzyl-pyrrolidin-3-yl)-(5-chloro-2-nitro-phenyl)-amine (1026490-44-7) → 5-(1H-imidazol-1-yl)-2-nitro-N-(1-benzyl-3-pyrrolidinyl)aniline (181869-99-8)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 120 ℃; for 2h; Yield given;

DOI:10.1021/jm960387+

upstream raw materials:

4-chloro-2-fluoro-nitrobenzene

1-Benzyl-3-aminopyrrolidine

Downstream raw materials:

5-(1H-imidazol-1-yl)-2-nitro-N-(1-benzyl-3-pyrrolidinyl)aniline