1,1-dimethylethyl ((1R)-1-methyl-2-{[6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinyl]amino}-2-oxoethyl)carbamate

Base Information

Chemical Name:1,1-dimethylethyl ((1R)-1-methyl-2-{[6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinyl]amino}-2-oxoethyl)carbamate
CAS No.:1311137-96-8
Molecular Formula:C₂₂H₂₉N₃O₅
Molecular Weight:415.489
Hs Code.:

Synonyms:1,1-dimethylethyl ((1R)-1-methyl-2-{[6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinyl]amino}-2-oxoethyl)carbamate

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Chemical Property of 1,1-dimethylethyl ((1R)-1-methyl-2-{[6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinyl]amino}-2-oxoethyl)carbamate

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Technology Process of 1,1-dimethylethyl ((1R)-1-methyl-2-{[6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinyl]amino}-2-oxoethyl)carbamate

There total 5 articles about 1,1-dimethylethyl ((1R)-1-methyl-2-{[6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinyl]amino}-2-oxoethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3744-87-4,7764-95-6,15761-38-3
Boc-(R)-Ala

: 1311137-94-6
6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinamine

: 1311137-96-8
1,1-dimethylethyl ((1R)-1-methyl-2-{[6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinyl]amino}-2-oxoethyl)carbamate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 110 ℃; for 3h; Microwave irradiation;

Reference yield:

: 108-46-3
recorcinol

: 1311137-96-8
1,1-dimethylethyl ((1R)-1-methyl-2-{[6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinyl]amino}-2-oxoethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethanol; water / 3.5 h / Reflux

1.3: pH 5

2.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C

2.2: 2 h / 120 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 110 °C / Microwave irradiation

With potassium tert-butylate; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; palladium 10% on activated carbon; In methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 68792-12-1
3-isopropoxyphenol

: 1311137-96-8
1,1-dimethylethyl ((1R)-1-methyl-2-{[6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinyl]amino}-2-oxoethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C

1.2: 2 h / 120 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 110 °C / Microwave irradiation

With potassium tert-butylate; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;