N'-[6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinyl]-D-alaninamide

Base Information

• Chemical Name: N'-[6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinyl]-D-alaninamide
• CAS No.: 1311137-97-9
• Molecular Formula: C₁₇H₂₁N₃O₃
• Molecular Weight: 315.372
• Mol file: 1311137-97-9.mol

Synonyms:N'-[6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinyl]-D-alaninamide

Chemical Property of N'-[6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinyl]-D-alaninamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-[6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinyl]-D-alaninamide

There total 5 articles about N'-[6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinyl]-D-alaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethyl ((1R)-1-methyl-2-{[6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinyl]amino}-2-oxoethyl)carbamate (1311137-96-8) → N'-[6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinyl]-D-alaninamide (1311137-97-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2.25h;

Reference yield:

recorcinol (108-46-3) → N'-[6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinyl]-D-alaninamide (1311137-97-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethanol; water / 3.5 h / Reflux

1.3: pH 5

2.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C

2.2: 2 h / 120 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 110 °C / Microwave irradiation

5.1: trifluoroacetic acid / dichloromethane / 2.25 h / 0 - 20 °C

With potassium tert-butylate; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

3-isopropoxyphenol (68792-12-1) → N'-[6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinyl]-D-alaninamide (1311137-97-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium tert-butylate / dimethyl sulfoxide / 0.5 h / 20 °C

1.2: 2 h / 120 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 3 h / 110 °C / Microwave irradiation

4.1: trifluoroacetic acid / dichloromethane / 2.25 h / 0 - 20 °C

With potassium tert-butylate; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

upstream raw materials:

recorcinol

3-isopropoxyphenol

2-({3-[(1-methylethyl)oxy]phenyl}oxy)-5-nitropyridine

6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinamine

Downstream raw materials:

(5R)-5-methyl-3-[6-({3-[(1-methylethyl)oxy]phenyl}oxy)-3-pyridinyl]-2,4-imidazolidinedione

Refernces