Technology Process of C24H31N3O4
There total 21 articles about C24H31N3O4 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C17H22BrNO4; 6-(dimethylamino)pyridin-3-ylboronic acid;
With
sodium hydrogencarbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; water;
at 80 ℃;
for 1h;
Inert atmosphere;
With
hydrogenchloride;
In
water;
pH=~ 2;
With
sodium carbonate;
In
water;
pH=~ 6;
- Guidance literature:
-
In
toluene;
Reflux;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydrogencarbonate; sodium hypochlorite; sodium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; water / 0 °C
2.1: formic acid / water; methanol / 24 h / 40 °C
3.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C / Inert atmosphere
3.2: 0.33 h / -78 °C
3.3: -40 °C
4.1: Chiralpak Daicel.(R). AD-20 / isopropyl alcohol / Resolution of racemate
5.1: hydrogen / tetrahydrofuran / 3 h / 25 °C
6.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere
6.2: pH ~ 2
6.3: pH ~ 6
7.1: toluene / Reflux
With
sodium hypochlorite; n-butyllithium; formic acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; hydrogen; sodium hydrogencarbonate; diisopropylamine; sodium bromide;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; isopropyl alcohol; toluene;
