4-(5-(2,4-dimethoxyphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

Base Information

Chemical Name:4-(5-(2,4-dimethoxyphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
CAS No.:1346457-91-7
Molecular Formula:C₂₃H₂₂FN₃O₄S
Molecular Weight:455.51
Hs Code.:

Synonyms:4-(5-(2,4-dimethoxyphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

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Chemical Property of 4-(5-(2,4-dimethoxyphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

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Technology Process of 4-(5-(2,4-dimethoxyphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

There total 3 articles about 4-(5-(2,4-dimethoxyphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 17852-52-7,27918-19-0
4-hydrazinobenzene-1-sulfonamide hydrochloride

: (E)-1-(4-fluorophenyl)-3-(2,4-dimethoxyphenyl)prop-2-en-1-one

: 1346457-91-7
4-(5-(2,4-dimethoxyphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

Guidance literature:: With acetic acid; In ethanol; for 12h; Reflux;
DOI:10.1007/s00044-011-9823-x

Reference yield: 48.0%

: 336101-27-0
C₁₇H₁₅FO₃

: 17852-52-7,27918-19-0
4-hydrazinobenzene-1-sulfonamide hydrochloride

: 1346457-91-7
4-(5-(2,4-dimethoxyphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

Guidance literature:: With acetic acid; In ethanol; for 17h; Reflux;
DOI:10.1016/j.bioorg.2018.12.028

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 1346457-91-7
4-(5-(2,4-dimethoxyphenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol / 18 h / 20 °C

2: acetic acid / ethanol / 12 h / Reflux

With acetic acid; sodium hydroxide; In methanol; ethanol;
DOI:10.1007/s00044-011-9823-x