4-[4-Fluoro-2-(tetrahydro-pyran-4-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (4-methyl-morpholin-2-ylmethyl)-amide trifluoracetate

Base Information

• Chemical Name: 4-[4-Fluoro-2-(tetrahydro-pyran-4-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (4-methyl-morpholin-2-ylmethyl)-amide trifluoracetate
• CAS No.: 1332710-62-9
• Molecular Formula: C₂HF₃O₂*C₂₅H₃₀FN₅O₄S
• Molecular Weight: 629.633
• Mol file: 1332710-62-9.mol

Synonyms:4-[4-Fluoro-2-(tetrahydro-pyran-4-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (4-methyl-morpholin-2-ylmethyl)-amide trifluoracetate

Chemical Property of 4-[4-Fluoro-2-(tetrahydro-pyran-4-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (4-methyl-morpholin-2-ylmethyl)-amide trifluoracetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[4-Fluoro-2-(tetrahydro-pyran-4-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (4-methyl-morpholin-2-ylmethyl)-amide trifluoracetate

There total 6 articles about 4-[4-Fluoro-2-(tetrahydro-pyran-4-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (4-methyl-morpholin-2-ylmethyl)-amide trifluoracetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-fluoro-2-(tetrahydro-2H-pyran-4-yloxy)phenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid (1211757-62-8) + 1-(4-methylmorpholin-2-yl)methylamine (141814-57-5) + trifluoroacetic acid (76-05-1) → 4-[4-Fluoro-2-(tetrahydro-pyran-4-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (4-methyl-morpholin-2-ylmethyl)-amide trifluoracetate (1332710-62-9)

Guidance literature:

4-(4-fluoro-2-(tetrahydro-2H-pyran-4-yloxy)phenylamino)-5-methylthieno[2,3-d]pyrimidine-6-carboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

1-(4-methylmorpholin-2-yl)methylamine; In N,N-dimethyl-formamide; at 20 ℃;

trifluoroacetic acid; In methanol; water; RP-chromatography;

Reference yield:

Tetrahydro-pyran-4-ol (2081-44-9) → 4-[4-Fluoro-2-(tetrahydro-pyran-4-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (4-methyl-morpholin-2-ylmethyl)-amide trifluoracetate (1332710-62-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 20 °C / Cooling with ice

2.1: hydrogen / palladium on activated charcoal / ethyl acetate / 20 °C / 2585.81 Torr

3.1: hydrogenchloride / 1,4-dioxane / 100 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 5 h / 20 °C

4.2: pH 2

5.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C

5.2: 20 °C

5.3: RP-chromatography

With hydrogenchloride; di-isopropyl azodicarboxylate; water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

5-fluoro-2-nitrophenol (446-36-6) → 4-[4-Fluoro-2-(tetrahydro-pyran-4-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid (4-methyl-morpholin-2-ylmethyl)-amide trifluoracetate (1332710-62-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 20 °C / Cooling with ice

2.1: hydrogen / palladium on activated charcoal / ethyl acetate / 20 °C / 2585.81 Torr

3.1: hydrogenchloride / 1,4-dioxane / 100 °C

4.1: water; lithium hydroxide / tetrahydrofuran / 5 h / 20 °C

4.2: pH 2

5.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C

5.2: 20 °C

5.3: RP-chromatography

With hydrogenchloride; di-isopropyl azodicarboxylate; water; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

Tetrahydro-pyran-4-ol

5-fluoro-2-nitrophenol

4-fluoro-2-(tetrahydro-2H-pyran-4-yloxy)aniline

4-[4-Fluoro-2-(tetrahydro-pyran-4-yloxy)-phenylamino]-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester