446-36-6

Basic information

• Product Name: 5-Fluoro-2-nitrophenol
• Synonyms: 2-Nitro-5-Fluorophenol;5-Fluoro-2-nitrophenol,98%;5-Fluoro-2-nitrophenol 99%;5-Fluoro-2-nitrophenol99%;5-FLUORO-2-NITROPHENOL,2-NITRO-5-FLUOROPHENOL;PHENOL,5-FLUORO-2-NITRO;6-Nitro-3-fluorophenol;4-Fluoro-2-hydroxynitrobenzene
• CAS NO: 446-36-6
• Molecular Formula: C₆H₄FNO₃
• Molecular Weight: 157.1
• EINECS: 207-168-6
• Product Categories: blocks;FluoroCompounds;NitroCompounds;Aromatic Phenols;Benzene series;Phenol&Thiophenol&Mercaptan;Fluorobenzene;Organic Building Blocks;Oxygen Compounds;Phenols;Alphabetic;F;FA - FLOrganic Building Blocks
• Mol File: 446-36-6.mol
• Article Data: 12

Chemical Properties

• Melting Point: 34-37 °C(lit.)
• Boiling Point: 260°C
• Flash Point: 197 °F
• Appearance: yellow/Powder, Crystals or Crystalline Mass and/or Chunks
• Density: 1.4306 (estimate)
• Vapor Pressure: 0.0486mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 6.18±0.13(Predicted)
• Water Solubility: slightly soluble
• BRN: 1870311
• CAS DataBase Reference: 5-Fluoro-2-nitrophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoro-2-nitrophenol(446-36-6)
• EPA Substance Registry System: 5-Fluoro-2-nitrophenol(446-36-6)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37-36/37/39-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 446-36-6(Hazardous Substances Data)

Usage

Description

5-Fluoro-2-nitrophenol is an organic compound characterized by its white to light yellow crystal powder appearance. It is a derivative of nitrophenol, which is known for its chemical reactivity and potential applications in various fields.

Uses

Used in Pharmaceutical Synthesis:
5-Fluoro-2-nitrophenol is used as a key intermediate in the total synthesis of the (+/?)-CC-1065, a potent antineoplastic agent. Its unique chemical structure contributes to the development of this therapeutic compound.
Used in Organic Chemistry:
5-Fluoro-2-nitrophenol serves as a starting material for the synthesis of 2-(7-fluoro-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)-4,5,6,7-tetrahydro-2H-isoindoline-1,3-diones. These organic molecules have potential applications in the pharmaceutical industry due to their diverse chemical properties.
Used in the Synthesis of Bioactive Molecules:
5-Fluoro-2-nitrophenol is also utilized in the synthesis of 7-substituted 2H-1,4-benzoxazin-3-(4H)-ones, which are compounds with therapeutic potential. These molecules act as inhibitors of angiogenesis, a process crucial for tumor growth and metastasis, making them valuable in the development of anti-cancer drugs.

InChI:InChI=1/C6H4FNO3/c7-4-1-2-5(8(10)11)6(9)3-4/h1-3,9H/p-1

Upstream product

• 372-20-3 3-fluorophenol 
• 7664-93-9 sulfuric acid 
• 64-19-7 acetic acid 
• 446-35-5 2,4-Difluoronitrobenzene 
• 7631-86-9 SiO₂ 
• 448-19-1 4-fluoro-2-methoxy-1-nitrobenzene 
• 2369-11-1 5-fluoro-2-nitroaniline 

Downstream Products

• 395-83-5 3-nitro-benzenesulfonic acid-(5-fluoro-2-nitro-phenyl ester) 
• 157831-78-2 3-fluoro-6-nitro-2,4-bis(piperidin-1'-ylmethyl)phenol 
• 53981-24-1 2-amino-5-fluorophenol 
• 28987-46-4 4-fluoro-1-nitro-2-(propan-2-yloxy)benzene 
• 367-32-8 4-fluoropyrocatechol 
• 367-82-8 3-Fluoro-4,6-dinitrophenol 
• 361-45-5 3-fluoro-2,4,6-trinitro-phenol 
• 191096-37-4 dihydro-3-(5-fluoro-2-nitrophenoxy)-2(3H)-furanone 
• 851190-65-3 2-methyl-2-(5-fluoro-2-nitrophenoxy)propionic acid ethyl ester 
• 218301-73-6 5-(2-methylimidazol-1-yl)-2-nitrophenol 
• 175135-19-0 AMA₅₆ 
• 135838-04-9 6-fluoroquinolin-8-ol 
• 473732-51-3 C₁₃H₁₆FNO₃ 

Relevant articles and documents

Production process of flumioxazin herbicide

The invention discloses a production process of a flumioxazin herbicide. The process is characterized by comprising the following steps: S1, synthesizing 2-nitro-5-fluorophenol; S2, synthesizing ethyl 2-(5-fluoro-2-nitrophenoxy) acetate; S3, synthesizing 7-fluoro-2H-1, 4-benzoxazine-3 (4H)-ketone; S4, synthesizing 7-fluoro-6-nitro-2H-1, 4-benzoxazine-3 (4H)-ketone; S5, synthesizing 7-fluoro-6-amino-2H-1, 4-benzoxazine-3 (4H)-ketone; S6, synthesizing 7-fluoro-6-(3, 4, 5, 6-tetrahydro)phthalimido-1, 4-benzoxazine-3 (4H) ketone; and S7, synthesizing the flumioxazin. The method has the advantages of low raw material price, few byproducts and light pollution.

5-fluoro-2-nitrophenol preparation method

The invention belongs to the field of organic synthesis, and particularly relates to a 5-fluoro-2-nitrophenol preparation method. In the prior art, the existing synthesis method has disadvantages of low conversion rate and long reaction time so as not to easily achieve industrial operation. A purpose of the present invention is to solve the technical problem in the prior art. The technical schemeis to provide a 5-fluoro-2-nitrophenol preparation method, which comprises: a) carrying out a reaction on 2,4-difluoronitrobenzene and NH 3 to obtain 5-fluoro-2-nitroaniline; and b) carrying out a reaction on the 5-fluoro-2-nitroaniline under the actions of sulfuric acid and sodium nitrite to obtain the 5-fluoro-2-nitrophenol. According to the present invention, the 5-fluoro-2-nitrophenol preparation method has advantages of good selectivity, almost no side reaction, high yield, short reaction time, simple operation and easy industrialization.

Spiro aryl phosphorus oxide or sulfide

The invention discloses a spiro aryl phosphorus oxide or sulfide as ALK inhibitor, and in particular discloses a compound shown in a formula (I) as an ALK inhibitor or a pharmaceutically acceptable salt thereof.