tert-butyl (3-((5-fluoro-2-((3-hydroxy-4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)carbamate

Base Information

Chemical Name:tert-butyl (3-((5-fluoro-2-((3-hydroxy-4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)carbamate
CAS No.:1616380-69-8
Molecular Formula:C₂₄H₂₈FN₅O₅
Molecular Weight:485.515
Hs Code.:

Synonyms:tert-butyl (3-((5-fluoro-2-((3-hydroxy-4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)carbamate

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Chemical Property of tert-butyl (3-((5-fluoro-2-((3-hydroxy-4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)carbamate

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Technology Process of tert-butyl (3-((5-fluoro-2-((3-hydroxy-4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)carbamate

There total 11 articles about tert-butyl (3-((5-fluoro-2-((3-hydroxy-4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 433226-25-6
2-(benzyloxy)-1-fluoro-4-nitrobenzene

: 1616380-69-8
tert-butyl (3-((5-fluoro-2-((3-hydroxy-4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / 2 h / 80 °C

2: ethanol; tin(ll) chloride / 3 h / 80 °C

3: acetic acid / ethanol / 24 h / Reflux

4: palladium on activated charcoal; hydrogen / ethanol / 50 h / 20 °C / 7240.26 Torr / Autoclave; Inert atmosphere

With ethanol; palladium on activated charcoal; hydrogen; caesium carbonate; acetic acid; tin(ll) chloride; In ethanol;

Reference yield:

: 22510-08-3
2-fluoro-5-nitrophenol

: 1616380-69-8
tert-butyl (3-((5-fluoro-2-((3-hydroxy-4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C

1.2: 18 h / 80 °C

2.1: caesium carbonate / 2 h / 80 °C

3.1: ethanol; tin(ll) chloride / 3 h / 80 °C

4.1: acetic acid / ethanol / 24 h / Reflux

5.1: palladium on activated charcoal; hydrogen / ethanol / 50 h / 20 °C / 7240.26 Torr / Autoclave; Inert atmosphere

With ethanol; palladium on activated charcoal; hydrogen; potassium carbonate; caesium carbonate; acetic acid; tin(ll) chloride; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1616380-60-9
2-(benzyloxy)-1-(2-methoxyethoxy)-4-nitrobenzene

: 1616380-69-8
tert-butyl (3-((5-fluoro-2-((3-hydroxy-4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol; tin(ll) chloride / 3 h / 80 °C

2: acetic acid / ethanol / 24 h / Reflux

3: palladium on activated charcoal; hydrogen / ethanol / 50 h / 20 °C / 7240.26 Torr / Autoclave; Inert atmosphere

With ethanol; palladium on activated charcoal; hydrogen; acetic acid; tin(ll) chloride; In ethanol;