5-((4-((3-aminophenyl)amino)-5-fluoropyrimidin-2-yl)amino)-2-(2-methoxyethoxyl)phenol

Base Information

Chemical Name:5-((4-((3-aminophenyl)amino)-5-fluoropyrimidin-2-yl)amino)-2-(2-methoxyethoxyl)phenol
CAS No.:1616380-71-2
Molecular Formula:C₁₉H₂₀FN₅O₃
Molecular Weight:385.398
Hs Code.:

Synonyms:5-((4-((3-aminophenyl)amino)-5-fluoropyrimidin-2-yl)amino)-2-(2-methoxyethoxyl)phenol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-((4-((3-aminophenyl)amino)-5-fluoropyrimidin-2-yl)amino)-2-(2-methoxyethoxyl)phenol

Chemical Property:

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Technology Process of 5-((4-((3-aminophenyl)amino)-5-fluoropyrimidin-2-yl)amino)-2-(2-methoxyethoxyl)phenol

There total 12 articles about 5-((4-((3-aminophenyl)amino)-5-fluoropyrimidin-2-yl)amino)-2-(2-methoxyethoxyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616380-69-8
tert-butyl (3-((5-fluoro-2-((3-hydroxy-4-(2-methoxyethoxyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)carbamate

: 1616380-71-2
5-((4-((3-aminophenyl)amino)-5-fluoropyrimidin-2-yl)amino)-2-(2-methoxyethoxyl)phenol

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 0.75h;

Reference yield:

: 433226-25-6
2-(benzyloxy)-1-fluoro-4-nitrobenzene

: 1616380-71-2
5-((4-((3-aminophenyl)amino)-5-fluoropyrimidin-2-yl)amino)-2-(2-methoxyethoxyl)phenol

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / 2 h / 80 °C

2: ethanol; tin(ll) chloride / 3 h / 80 °C

3: acetic acid / ethanol / 24 h / Reflux

4: palladium on activated charcoal; hydrogen / ethanol / 50 h / 20 °C / 7240.26 Torr / Autoclave; Inert atmosphere

5: trifluoroacetic acid / dichloromethane / 0.75 h / 0 - 20 °C

With ethanol; palladium on activated charcoal; hydrogen; caesium carbonate; acetic acid; trifluoroacetic acid; tin(ll) chloride; In ethanol; dichloromethane;

Reference yield:

: 22510-08-3
2-fluoro-5-nitrophenol

: 1616380-71-2
5-((4-((3-aminophenyl)amino)-5-fluoropyrimidin-2-yl)amino)-2-(2-methoxyethoxyl)phenol

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C

1.2: 18 h / 80 °C

2.1: caesium carbonate / 2 h / 80 °C

3.1: ethanol; tin(ll) chloride / 3 h / 80 °C

4.1: acetic acid / ethanol / 24 h / Reflux

5.1: palladium on activated charcoal; hydrogen / ethanol / 50 h / 20 °C / 7240.26 Torr / Autoclave; Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 - 20 °C

With ethanol; palladium on activated charcoal; hydrogen; potassium carbonate; caesium carbonate; acetic acid; trifluoroacetic acid; tin(ll) chloride; In ethanol; dichloromethane; N,N-dimethyl-formamide;