(+)-(2S)-Dimethyl 2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>pentane-1,5-dioate

Base Information

Chemical Name:(+)-(2S)-Dimethyl 2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>pentane-1,5-dioate
CAS No.:151075-02-4
Molecular Formula:C₁₇H₂₁NO₆
Molecular Weight:335.357
Hs Code.:

Synonyms:(+)-(2S)-Dimethyl 2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>pentane-1,5-dioate

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Chemical Property of (+)-(2S)-Dimethyl 2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>pentane-1,5-dioate

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Technology Process of (+)-(2S)-Dimethyl 2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>pentane-1,5-dioate

There total 7 articles about (+)-(2S)-Dimethyl 2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>pentane-1,5-dioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: (+)-(2S)-Dimethyl 2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>-(3E)-pentene-1,5-dioate

: 151075-02-4
(+)-(2S)-Dimethyl 2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>pentane-1,5-dioate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 25 ℃; for 16h; under 1551.4 Torr;
DOI:10.1021/jo00074a016

Reference yield:

: 134627-50-2
(6S,7S)-7-<(4S)-2-Oxo-4-phenyl-1,3-oxazolidin-3-yl>-1-aza-5-oxabicyclo<4.2.0>octan-8-one

: 151075-02-4
(+)-(2S)-Dimethyl 2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>pentane-1,5-dioate

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / KHMDS / toluene; tetrahydrofuran; dimethylformamide / 1.) -78 deg C, 1 h, 2.) -78 deg C, 15 min

2: HCl / methanol / 24 h / 25 °C

3: 50 percent / 1 N HCl / tetrahydrofuran / 48 h / 25 °C

4: 92 percent / tetrahydrofuran / 72 h / 25 °C

5: 85 percent / H₂ / 10percent Pd/C / methanol / 16 h / 25 °C / 1551.4 Torr

With hydrogenchloride; hydrogen; potassium hexamethylsilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00074a016

Reference yield:

: (6S,7S)-7-((S)-2-Hydroxy-1-phenyl-ethylamino)-5-oxa-1-aza-bicyclo[4.2.0]octan-8-one

: 151075-02-4
(+)-(2S)-Dimethyl 2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>pentane-1,5-dioate

Guidance literature:: Multi-step reaction with 6 steps

1: i-Pr₂NEt / CH₂Cl₂ / 0.75 h / 0 °C

2: 80 percent / KHMDS / toluene; tetrahydrofuran; dimethylformamide / 1.) -78 deg C, 1 h, 2.) -78 deg C, 15 min

3: HCl / methanol / 24 h / 25 °C

4: 50 percent / 1 N HCl / tetrahydrofuran / 48 h / 25 °C

5: 92 percent / tetrahydrofuran / 72 h / 25 °C

6: 85 percent / H₂ / 10percent Pd/C / methanol / 16 h / 25 °C / 1551.4 Torr

With hydrogenchloride; hydrogen; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00074a016