Technology Process of (+)-(2S)-Dimethyl 2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>pentane-1,5-dioate
There total 7 articles about (+)-(2S)-Dimethyl 2-methyl-2-<(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl>pentane-1,5-dioate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol;
at 25 ℃;
for 16h;
under 1551.4 Torr;
DOI:10.1021/jo00074a016
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 80 percent / KHMDS / toluene; tetrahydrofuran; dimethylformamide / 1.) -78 deg C, 1 h, 2.) -78 deg C, 15 min
2: HCl / methanol / 24 h / 25 °C
3: 50 percent / 1 N HCl / tetrahydrofuran / 48 h / 25 °C
4: 92 percent / tetrahydrofuran / 72 h / 25 °C
5: 85 percent / H2 / 10percent Pd/C / methanol / 16 h / 25 °C / 1551.4 Torr
With
hydrogenchloride; hydrogen; potassium hexamethylsilazane;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00074a016
- Guidance literature:
-
Multi-step reaction with 6 steps
1: i-Pr2NEt / CH2Cl2 / 0.75 h / 0 °C
2: 80 percent / KHMDS / toluene; tetrahydrofuran; dimethylformamide / 1.) -78 deg C, 1 h, 2.) -78 deg C, 15 min
3: HCl / methanol / 24 h / 25 °C
4: 50 percent / 1 N HCl / tetrahydrofuran / 48 h / 25 °C
5: 92 percent / tetrahydrofuran / 72 h / 25 °C
6: 85 percent / H2 / 10percent Pd/C / methanol / 16 h / 25 °C / 1551.4 Torr
With
hydrogenchloride; hydrogen; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00074a016
