(S)-ethyl 4-(tert-butoxycarbonylamino)-5-(4-methoxyphenyl)-3-oxopentanoate

Base Information

Chemical Name:(S)-ethyl 4-(tert-butoxycarbonylamino)-5-(4-methoxyphenyl)-3-oxopentanoate
CAS No.:1345837-37-7
Molecular Formula:C₁₉H₂₇NO₆
Molecular Weight:365.426
Hs Code.:

Synonyms:(S)-ethyl 4-(tert-butoxycarbonylamino)-5-(4-methoxyphenyl)-3-oxopentanoate

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Chemical Property of (S)-ethyl 4-(tert-butoxycarbonylamino)-5-(4-methoxyphenyl)-3-oxopentanoate

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Technology Process of (S)-ethyl 4-(tert-butoxycarbonylamino)-5-(4-methoxyphenyl)-3-oxopentanoate

There total 2 articles about (S)-ethyl 4-(tert-butoxycarbonylamino)-5-(4-methoxyphenyl)-3-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 623-73-4
diazoacetic acid ethyl ester

: 139183-60-1
N-t-butoxylcarbonyl-O-methyl-L-tyrosinal

: 1345837-37-7
(S)-ethyl 4-(tert-butoxycarbonylamino)-5-(4-methoxyphenyl)-3-oxopentanoate

Guidance literature:: With tin(ll) chloride; In dichloromethane; at 20 - 25 ℃; for 0.5h;
DOI:10.1039/c1ob05815k

Reference yield:

: 126395-29-7
[(S)-2-hydroxy-1-(4-methoxybenzyl)ethyl]carbamic acid tert-butyl ester

: 1345837-37-7
(S)-ethyl 4-(tert-butoxycarbonylamino)-5-(4-methoxyphenyl)-3-oxopentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate

2: tin(ll) chloride / dichloromethane / 0.5 h / 20 - 25 °C

With tin(ll) chloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dichloromethane; ethyl acetate;
DOI:10.1039/c1ob05815k

Reference yield:

: 1345837-37-7
(S)-ethyl 4-(tert-butoxycarbonylamino)-5-(4-methoxyphenyl)-3-oxopentanoate

: 1345837-41-3
(S)-tert-butyl 1-(7-methoxy-2-oxo-2H-chromen-4-yl)-2-(4-methoxyphenyl)ethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 0.5 h / Cooling

2.1: 0.08 h / 0 °C

2.2: 3 h / 0 °C

3.1: sodium carbonate / tetrahydrofuran / 5 h / 20 °C

With sodium carbonate; In tetrahydrofuran; dichloromethane; 2.1: Pechmann condensation;
DOI:10.1039/c1ob05815k