1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione

Base Information

Chemical Name:1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione
CAS No.:1197377-31-3
Molecular Formula:C₁₆H₁₅ClN₂O₃
Molecular Weight:318.76
Hs Code.:
Mol file:1197377-31-3.mol

Synonyms:1-(2-chloro-1-hydroxy-3-(quinolin-6-yl)propyl)pyrrolidine-2,5-dione

Suppliers and Price of 1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 22 raw suppliers

Chemical Property of 1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione

Chemical Property:

Vapor Pressure:0-0Pa at 20-25℃
Boiling Point:598.3±50.0 °C(Predicted)
PKA:11.45±0.20(Predicted)
Density:1.434±0.06 g/cm3(Predicted)

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of 1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione

There total 3 articles about 1-[2-Chloro-1-hydroxy-3-(6-quinolinyl)propyl]-2,5-pyrrolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 128-09-6
N-chloro-succinimide

: 476660-18-1
3-(quinolin-6-yl)propanal

: 1197377-31-3
1-(2-chloro-1-hydroxy-3-(quinolin-6-yl)propyl)pyrrolidine-2,5-dione

Guidance literature:: With benzoic acid; L-proline; In acetonitrile; at 0 - 20 ℃; Product distribution / selectivity;

Reference yield:

: 5332-25-2
6-bromoquinoline

: 1197377-31-3
1-(2-chloro-1-hydroxy-3-(quinolin-6-yl)propyl)pyrrolidine-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: tri tert-butylphosphoniumtetrafluoroborate; N-Methyldicyclohexylamine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 24 h / 30 °C / Inert atmosphere

2: L-proline / chloroform / 0 - 20 °C

With N-Methyldicyclohexylamine; L-proline; tri tert-butylphosphoniumtetrafluoroborate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; chloroform;

Reference yield:

: 1197377-26-6
6-(3,3-diethoxypropyl)quinoline

: 1197377-31-3
1-(2-chloro-1-hydroxy-3-(quinolin-6-yl)propyl)pyrrolidine-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / ethyl acetate; water

2: chloroform

With hydrogenchloride; In chloroform; water; ethyl acetate;