Technology Process of tert-butyl(((S,E)-6-((4S,5S)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl)-3-methylhex-5-en-1-yl)oxy)diphenylsilane
There total 11 articles about tert-butyl(((S,E)-6-((4S,5S)-2,2-dimethyl-5-vinyl-1,3-dioxolan-4-yl)-3-methylhex-5-en-1-yl)oxy)diphenylsilane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl-triphenylphosphonium iodide;
With
potassium hexamethylsilazane;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
Inert atmosphere;
C29H40O4Si;
In
tetrahydrofuran;
at -78 - 20 ℃;
Inert atmosphere;
DOI:10.1021/ol9025183
- Guidance literature:
-
Methyltriphenylphosphonium bromide;
With
sodium hexamethyldisilazane;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
C29H40O4Si;
In
tetrahydrofuran;
for 3h;
DOI:10.1039/c0ob01253j
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: lithium aluminium tetrahydride / 6 h / Reflux
2.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 24 h / 20 °C
3.1: tetrahydrofuran; N,N-dimethyl-formamide
4.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C
4.2: 6.25 h / -78 °C
5.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 20 °C
6.1: sulfur trioxide pyridine complex; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C
7.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C
7.2: 3 h
With
lithium aluminium tetrahydride; sodium hexamethyldisilazane; sulfur trioxide pyridine complex; sodium hydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
3.1: Swern oxidation / 4.1: Julia-Kocienski olefination / 4.2: Julia-Kocienski olefination / 6.1: Parikh-Doering oxidation / 7.1: Wittig methylenation / 7.2: Wittig methylenation;
DOI:10.1039/c0ob01253j
