4-(4-chlorophenyl)-2-[(2,4-dichlorophenyl)-hydrazono]-3-methyl-4-oxobutyric acid ethyl ester

Base Information

• Chemical Name: 4-(4-chlorophenyl)-2-[(2,4-dichlorophenyl)-hydrazono]-3-methyl-4-oxobutyric acid ethyl ester
• CAS No.: 170937-37-8
• Molecular Formula: C₁₉H₁₇Cl₃N₂O₃
• Molecular Weight: 427.715
• Mol file: 170937-37-8.mol

Synonyms:4-(4-chlorophenyl)-2-[(2,4-dichlorophenyl)-hydrazono]-3-methyl-4-oxobutyric acid ethyl ester

Chemical Property of 4-(4-chlorophenyl)-2-[(2,4-dichlorophenyl)-hydrazono]-3-methyl-4-oxobutyric acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-chlorophenyl)-2-[(2,4-dichlorophenyl)-hydrazono]-3-methyl-4-oxobutyric acid ethyl ester

There total 10 articles about 4-(4-chlorophenyl)-2-[(2,4-dichlorophenyl)-hydrazono]-3-methyl-4-oxobutyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-(4-chlorophenyl)-3-methyl-2,4-dioxobutyric acid ethyl ester (169544-41-6) + (2,4-dichlorophenyl)hydrazine (13123-92-7) → 4-(4-chlorophenyl)-2-[(2,4-dichlorophenyl)-hydrazono]-3-methyl-4-oxobutyric acid ethyl ester (170937-37-8)

Guidance literature:

With acetic acid; In ethanol; at 80 ℃; for 3h; Reflux;

DOI:10.1080/00397911.2013.765483

Reference yield: 66.0%

4-(4-chlorophenyl)-3-methyl-2,4-dioxobutyric acid ethyl ester (169544-41-6) + (2,4-dichlorophenyl)hydrazine (13123-92-7) → 4-(4-chlorophenyl)-2-[(2,4-dichlorophenyl)-hydrazono]-3-methyl-4-oxobutyric acid ethyl ester (170937-37-8) + ethyl 1-(2,4-dichlorophenyl)-4-methyl-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylate (158941-22-1)

Guidance literature:

With acetic acid; for 12h; regioselective reaction; Reflux;

DOI:10.1016/j.tet.2012.11.012

Reference yield: 61.9%

2,4-dichlorophenyl hydrazine hydrochloride (5446-18-4) + 4-(4-chlorophenyl)-3-methyl-2,4-dioxobutyric acid ethyl ester (169544-41-6) → 4-(4-chlorophenyl)-2-[(2,4-dichlorophenyl)-hydrazono]-3-methyl-4-oxobutyric acid ethyl ester (170937-37-8)

Guidance literature:

With triethylamine; In ethanol; at 20 ℃; for 20h;

DOI:10.3109/14756366.2010.491794

upstream raw materials:

4-(4-chlorophenyl)-3-methyl-2,4-dioxobutyric acid ethyl ester

(2,4-dichlorophenyl)hydrazine

ethyl 4-(4-chlorophenyl)-3-methyl-4-oxydo-2-oxobuten-3-oate lithium salt

2,4-dichlorophenyl hydrazine hydrochloride

Downstream raw materials:

rimonabant

[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-yl]methanol

3-(bromomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxaldehyde