3-(bromomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole

Base Information

Chemical Name:3-(bromomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole
CAS No.:913624-95-0
Molecular Formula:C₁₇H₁₂BrCl₃N₂
Molecular Weight:430.559
Hs Code.:

Synonyms:3-(bromomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole

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Chemical Property of 3-(bromomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole

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Technology Process of 3-(bromomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole

There total 8 articles about 3-(bromomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 158941-22-1
ethyl 1-(2,4-dichlorophenyl)-4-methyl-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylate

: 913624-95-0
3-(bromomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / lithium aluminum hydride / diethyl ether / 20 °C

2: 35 percent / carbon tetrabromide; triphenylphosphine / diethyl ether / 3.5 h

With lithium aluminium tetrahydride; carbon tetrabromide; triphenylphosphine; In diethyl ether;
DOI:10.1021/jm060446b

Reference yield:

: 168272-78-4
5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid methyl ester

: 913624-95-0
3-(bromomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / diethyl ether / -15 °C

2: carbon tetrabromide; triphenylphosphine / 0 °C

With lithium aluminium tetrahydride; carbon tetrabromide; triphenylphosphine; In diethyl ether; 2: |Appel Halogenation;
DOI:10.1016/j.neuropharm.2019.107928

Reference yield:

: 6285-05-8
4'-chloropropiophenone

: 913624-95-0
3-(bromomethyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 7 steps

1: sodium iodide / acetonitrile / 5 h / 20 °C / Inert atmosphere

2: tert-butyl methyl ether / 5 h / 20 °C

3: 5 h / 20 °C

4: triethylamine / ethanol / 20 h / 20 °C

5: acetic acid / 24 h / Reflux

6: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 0 °C

7: phosphorus tribromide / benzene / 1 h / Reflux

With lithium aluminium tetrahydride; phosphorus tribromide; acetic acid; triethylamine; sodium iodide; In tetrahydrofuran; ethanol; tert-butyl methyl ether; acetonitrile; benzene;
DOI:10.3109/14756366.2010.491794