2,6-di-(3'-hydroxypropoxy)-4,8-bis(di-N,N-(3',4'-dimethoxybenzyl)amino)pyrimido[5,4-d]pyrimidine

Base Information

• Chemical Name: 2,6-di-(3'-hydroxypropoxy)-4,8-bis(di-N,N-(3',4'-dimethoxybenzyl)amino)pyrimido[5,4-d]pyrimidine
• CAS No.: 774539-28-5
• Molecular Formula: C₄₈H₅₈N₆O₁₂
• Molecular Weight: 911.022

Synonyms:2,6-di-(3'-hydroxypropoxy)-4,8-bis(di-N,N-(3',4'-dimethoxybenzyl)amino)pyrimido[5,4-d]pyrimidine

Chemical Property of 2,6-di-(3'-hydroxypropoxy)-4,8-bis(di-N,N-(3',4'-dimethoxybenzyl)amino)pyrimido[5,4-d]pyrimidine

Chemical Property:

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Technology Process of 2,6-di-(3'-hydroxypropoxy)-4,8-bis(di-N,N-(3',4'-dimethoxybenzyl)amino)pyrimido[5,4-d]pyrimidine

There total 8 articles about 2,6-di-(3'-hydroxypropoxy)-4,8-bis(di-N,N-(3',4'-dimethoxybenzyl)amino)pyrimido[5,4-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2,6-di-(3'-triisopropylsilyloxypropoxy)-4,8-bis(di-N,N-(3',4'-dimethoxybenzyl)amino)pyrimido[5,4-d]pyrimidine (774539-27-4) → 2,6-di-(3'-hydroxypropoxy)-4,8-bis(di-N,N-(3',4'-dimethoxybenzyl)amino)pyrimido[5,4-d]pyrimidine (774539-28-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 12h;

DOI:10.1021/jm040772w

Reference yield:

2,4,6,8-Tetrachloro-pyrimido[5,4-d]pyrimidine (32980-71-5) → 2,6-di-(3'-hydroxypropoxy)-4,8-bis(di-N,N-(3',4'-dimethoxybenzyl)amino)pyrimido[5,4-d]pyrimidine (774539-28-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 68 percent / K₂CO₃ / tetrahydrofuran / 25 °C

2.1: NaH / tetrahydrofuran / 0.08 h / 60 °C

2.2: 65 percent / tetrahydrofuran / Heating

3.1: 83 percent / TBAF / tetrahydrofuran / 12 h / 25 °C

With tetrabutyl ammonium fluoride; sodium hydride; potassium carbonate; In tetrahydrofuran;

DOI:10.1021/jm040772w

Reference yield:

N,N-bis-(3,4-dimethoxybenzyl)amine (5634-21-9) → 2,6-di-(3'-hydroxypropoxy)-4,8-bis(di-N,N-(3',4'-dimethoxybenzyl)amino)pyrimido[5,4-d]pyrimidine (774539-28-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 68 percent / K₂CO₃ / tetrahydrofuran / 25 °C

2.1: NaH / tetrahydrofuran / 0.08 h / 60 °C

2.2: 65 percent / tetrahydrofuran / Heating

3.1: 83 percent / TBAF / tetrahydrofuran / 12 h / 25 °C

With tetrabutyl ammonium fluoride; sodium hydride; potassium carbonate; In tetrahydrofuran;

DOI:10.1021/jm040772w

upstream raw materials:

2,6-di-(3'-triisopropylsilyloxypropoxy)-4,8-bis(di-N,N-(3',4'-dimethoxybenzyl)amino)pyrimido[5,4-d]pyrimidine

2,4,6,8-Tetrachloro-pyrimido[5,4-d]pyrimidine

N,N-bis-(3,4-dimethoxybenzyl)amine

N-(3,4-dimethoxybenzyl)-1-(3,4-dimethoxyphenyl)methanimine

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