tert-butyl (S)-(1-(3',5'-dichloro-[1,1'-biphenyl]-4-yl)-3-oxopropan-2-yl)carbamate

Base Information

Chemical Name:tert-butyl (S)-(1-(3',5'-dichloro-[1,1'-biphenyl]-4-yl)-3-oxopropan-2-yl)carbamate
CAS No.:1431556-34-1
Molecular Formula:C₂₀H₂₁Cl₂NO₃
Molecular Weight:394.298
Hs Code.:

Synonyms:tert-butyl (S)-(1-(3',5'-dichloro-[1,1'-biphenyl]-4-yl)-3-oxopropan-2-yl)carbamate

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Chemical Property of tert-butyl (S)-(1-(3',5'-dichloro-[1,1'-biphenyl]-4-yl)-3-oxopropan-2-yl)carbamate

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Technology Process of tert-butyl (S)-(1-(3',5'-dichloro-[1,1'-biphenyl]-4-yl)-3-oxopropan-2-yl)carbamate

There total 2 articles about tert-butyl (S)-(1-(3',5'-dichloro-[1,1'-biphenyl]-4-yl)-3-oxopropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103882-09-3,62129-44-6
N-Boc-4-I-Phe-OH

: 1431556-34-1
tert-butyl (S)-(1-(3',5'-dichloro-[1,1'-biphenyl]-4-yl)-3-oxopropan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 48 h / 70 °C / Inert atmosphere

2: sodium hydrogencarbonate / N,N-dimethyl-formamide / 12 h / 20 °C

3: diisobutylaluminium hydride / dichloromethane; toluene / 12 h / 20 °C

4: Dess-Martin periodane / dichloromethane / 5 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; diisobutylaluminium hydride; sodium hydrogencarbonate; sodium carbonate; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1039/C8MD00320C

Reference yield:

: 67492-50-6
(3,5-dichlorophenyl)boronic acid

: 266306-18-7
(S)-3-(4-Bromo-phenyl)-2-tert-butoxycarbonylamino-propionic acid methyl ester

: 1431556-34-1
tert-butyl (S)-(1-(3',5'-dichloro-[1,1'-biphenyl]-4-yl)-3-oxopropan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine

2: diisobutylaluminium hydride / toluene

With diisobutylaluminium hydride; triethylamine; In toluene;