(3R,4S)-4-[cyclopropyl-(3-fluoro-4-[1,2,4]triazol-1-yl-benzoyl)-amino]-3-fluoro-piperidine-1-carboxylic acid isopropyl ester

Base Information

Chemical Name:(3R,4S)-4-[cyclopropyl-(3-fluoro-4-[1,2,4]triazol-1-yl-benzoyl)-amino]-3-fluoro-piperidine-1-carboxylic acid isopropyl ester
CAS No.:1578188-86-9
Molecular Formula:C₂₁H₂₅F₂N₅O₃
Molecular Weight:433.458
Hs Code.:

Synonyms:(3R,4S)-4-[cyclopropyl-(3-fluoro-4-[1,2,4]triazol-1-yl-benzoyl)-amino]-3-fluoro-piperidine-1-carboxylic acid isopropyl ester

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Chemical Property of (3R,4S)-4-[cyclopropyl-(3-fluoro-4-[1,2,4]triazol-1-yl-benzoyl)-amino]-3-fluoro-piperidine-1-carboxylic acid isopropyl ester

Chemical Property:

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Technology Process of (3R,4S)-4-[cyclopropyl-(3-fluoro-4-[1,2,4]triazol-1-yl-benzoyl)-amino]-3-fluoro-piperidine-1-carboxylic acid isopropyl ester

There total 3 articles about (3R,4S)-4-[cyclopropyl-(3-fluoro-4-[1,2,4]triazol-1-yl-benzoyl)-amino]-3-fluoro-piperidine-1-carboxylic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1020934-33-1
3-fluoro-4-(1H-1,2,4-triazol-1-yl)benzoic acid

: 1557038-72-8
(3R,4S)-4-cyclopropylamino-3-fluoro-piperidine-1-carboxylic acid isopropyl ester

: 1578188-86-9
(3R,4S)-4-[cyclopropyl-(3-fluoro-4-[1,2,4]triazol-1-yl-benzoyl)-amino]-3-fluoro-piperidine-1-carboxylic acid isopropyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 144267-96-9
ethyl 3,4-difluorobenzoate

: 1578188-86-9
(3R,4S)-4-[cyclopropyl-(3-fluoro-4-[1,2,4]triazol-1-yl-benzoyl)-amino]-3-fluoro-piperidine-1-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 150 °C / Microwave irradiation

2: sodium hydroxide; water / methanol / 1 h / 20 °C

3: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

With water; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; sodium hydroxide; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1400706-96-8
C₁₁H₁₀FN₃O₂

: 1578188-86-9
(3R,4S)-4-[cyclopropyl-(3-fluoro-4-[1,2,4]triazol-1-yl-benzoyl)-amino]-3-fluoro-piperidine-1-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / methanol / 1 h / 20 °C

2: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C

With water; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; sodium hydroxide; In methanol; N,N-dimethyl-formamide;