144267-96-9

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 3,4-DIFLUOROBENZOATE is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be incorporated into the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, ETHYL 3,4-DIFLUOROBENZOATE serves as an essential intermediate for the production of agrochemicals. Its properties make it suitable for the synthesis of compounds that can be used in crop protection and other agricultural applications.
Used in Fragrance and Flavoring Industry:
ETHYL 3,4-DIFLUOROBENZOATE is utilized in the production of fragrances and flavorings due to its aromatic properties. Its fruity odor makes it a valuable component in creating scents and tastes for various consumer products, enhancing the sensory experience.

Upstream product

• 64-17-5 ethanol 
• 455-86-7 3,4-Difluorobenzoic acid 

Downstream Products

• 216076-14-1 1-(3,4-difluoro-phenyl)-2-pyridin-4-yl-ethanone 
• 863505-06-0 ethyl 3-fluoro-4-{3-[(1S)-2-methoxy-1-methylethoxy]-5-[(1H-pyrazol-3-ylamino)carbonyl]phenoxy}benzoate 
• 871657-48-6 ethyl 3-fluoro-4-(3-[(1S)-2-hydroxy-1-methylethoxy]-5-{[(1-methyl-1H-pyrazol-3-yl)amino]carbonyl}phenoxy)benzoate 
• 1020934-33-1 3-fluoro-4-(1H-1,2,4-triazol-1-yl)benzoic acid 
• 1021235-17-5 3-fluoro-4-(2-methyl-1H-imidazol-1-yl)benzoic acid 
• 1400706-96-8 C₁₁H₁₀FN₃O₂ 
• 1400706-97-9 C₁₃H₁₃FN₂O₂ 
• 71682-97-8 3-(3,4-difluorophenyl)-3-oxopropanenitrile 
• 73792-12-8 ethyl 4-amino-3-fluorobenzoate 
• 1578188-86-9 (3R,4S)-4-[cyclopropyl-(3-fluoro-4-[1,2,4]triazol-1-yl-benzoyl)-amino]-3-fluoro-piperidine-1-carboxylic acid isopropyl ester 
• 861805-01-8 4-[4-(3,4-difluoro-phenyl)-4-oxo-3-pyridin-4-yl-butyryl]-piperidine-1-carboxylic acid benzyl ester 
• 861804-81-1 4-[5-(3,4-difluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-yl]-piperidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

The pollen tube growth regulator (by machine translation)

The pollen tube growth regulating agent [a]. (1) A compound represented by the general formula [a], a salt thereof, a solvate thereof selected from the group consisting of at least 1 kind, the pollen tube growth regulator. [Drawing] no (by machine translation)

Synthesis and antimicrobial activity of new prenylated 2-pyrone derivatives

A series of new monoprenylated and diprenylated 2-pyrone derivatives with different halogen substituents were synthesized from the corresponding 6-aryl-4-hydroxy-2-pyrones by prenylation reactions. The compounds were evaluated for antibacterial activity and displayed significant in vitro activity with the highest activity shown by the monoprenylated 6-aryl-2-pyrones. All the compounds except the bromine-containing analogs were active against one or more tested bacteria, with Escherichia coli being the most susceptible of the test organisms. With the remarkable antibacterial activity of eight of the compounds against a drug-resistant β-lactamase-producing Klebsiella pneumoniae, a synergistic evaluation between each of these compounds and ampicillin was undertaken. Out of the eight combinations studied, synergistic effects were observed with two compounds, 4-(3-methylbut-2-enoxy)-6-phenyl-2H-pyran-2-one and 6-(4-fluorophenyl)-4-(3-methylbut-2-enoxy)-2H-pyran-2-one. Both compounds, at half the individual MIC values, were able to lower the MIC of ampicillin in combinations from 2500 to 2.4 μg/mL (1/1041 of MIC).

2-PHENYLPYRIDIN-4-YL DERIVATIVES AS ALK5 INHIBITORS

This invention relates to novel 2-phenylpyridin-4-yl heterocyclyl derivatives which are inhibitors of the transforming growth factor, ("TGF")-? signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase ("ALK")-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.

NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND BENAMIDE COMPOUNDS AND DRUGS CONTAINING THE SAME

Disclosed are compounds represented by formula (I) which have triglyceride biosynthesis inhibitory activity in the liver and inhibitory activity against the secretion of apolipoprotein B-containing lipoprotein from the liver and particularly have excellent inhibitory activity against the secretion of apolipoprotein B-containing lipoprotein, are free from side effect of accumulation of lipids in the liver, and are useful for the treatment and prevention of hyperlipidemia and arteriosclerotic diseases. In formula (I), R1 and R2 represent alkyl, alkoxy, cycloalkyl, phenyl, alkenyl, alkynyl, or a five- or six-membered saturated or unsaturated heterocyclic ring, or R1 and R2, together with a nitrogen atom to which R1 and R2 are attached, may form a ring; R3 and R4 represent a hydrogen atom, alkyl, a halogen atom, hydroxyl, nitrile, alkoxycarbonyl, alkoxy, or carboxyl; or R2 and R3 may be attached to each other to form -(CH2)m-, -N=CH-, -CH=N-, or -(C1-6 alkyl)C=N-; A, D, E, and G each represent a carbon atom, or any one of A, D, E, and G represents a nitrogen atom with the other three each representing a carbon atom; Q represents a nitrogen atom or a carbon atom; Y represents a group represented by formula (II) wherein X represents a hydrogen atom, group -C(=O)N(R5)R6 or group -C(=O)OR7, R8 is absent or represents a bond, an oxygen atom, a sulfur atom, -SO2-, -SO-, -CH2-CH2-, or - CH=CH-, and R9 and R10 represent a hydrogen atom, alkyl, alkoxy, a halogen atom, or hydroxyl; and Z represents - (CH2)n-, -O-(CH2)i-, or -C(=O)NH-(CH2)i-.