methyl 1,2-dihydro-6,7-dimethyl-4-(2-methylphenyl)-2-oxo-3-quinolinecarboxylate

Base Information

Chemical Name:methyl 1,2-dihydro-6,7-dimethyl-4-(2-methylphenyl)-2-oxo-3-quinolinecarboxylate
CAS No.:136281-17-9
Molecular Formula:C₂₀H₁₉NO₃
Molecular Weight:321.376
Hs Code.:

Synonyms:methyl 1,2-dihydro-6,7-dimethyl-4-(2-methylphenyl)-2-oxo-3-quinolinecarboxylate

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Chemical Property of methyl 1,2-dihydro-6,7-dimethyl-4-(2-methylphenyl)-2-oxo-3-quinolinecarboxylate

Chemical Property:

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Technology Process of methyl 1,2-dihydro-6,7-dimethyl-4-(2-methylphenyl)-2-oxo-3-quinolinecarboxylate

There total 2 articles about methyl 1,2-dihydro-6,7-dimethyl-4-(2-methylphenyl)-2-oxo-3-quinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.6%

: 39619-07-3
2-methylmalonyl dichloride

: 2-amino-4,5,2'-trimethylbenzophenone

: 136281-17-9
methyl 1,2-dihydro-6,7-dimethyl-4-(2-methylphenyl)-2-oxo-3-quinolinecarboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In ethyl acetate; toluene;

Reference yield: 82.6%

: 2-amino-4,5,2'-trimethylbenzophenone

: 108-59-8
malonic acid dimethyl ester

: 136281-17-9
methyl 1,2-dihydro-6,7-dimethyl-4-(2-methylphenyl)-2-oxo-3-quinolinecarboxylate

Guidance literature:: With piperidine; at 170 ℃; for 4h;
DOI:10.1248/cpb.43.616

Reference yield:

: 136281-17-9
methyl 1,2-dihydro-6,7-dimethyl-4-(2-methylphenyl)-2-oxo-3-quinolinecarboxylate

: 1027601-27-9
3-Isocyanato-1,6,7-trimethyl-4-o-tolyl-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 3 h

2: 83.2 percent / KOH / ethanol; H₂O / 0.5 h / Heating

3: Et₃N, diphenyl phosphoryl azide / benzene / a) RT, 20 min, b) reflux, 40 min

With potassium hydroxide; diphenyl phosphoryl azide; sodium hydride; triethylamine; In ethanol; water; benzene;
DOI:10.1248/cpb.43.616