2',3'-benzylidene-5'-adenosine

Base Information

• Chemical Name: 2',3'-benzylidene-5'-adenosine
• CAS No.: 114958-16-6
• Molecular Formula: C₂₄H₂₀FN₅O₇S
• Molecular Weight: 541.517
• Mol file: 114958-16-6.mol

Synonyms:2',3'-benzylidene-5'-adenosine

Chemical Property of 2',3'-benzylidene-5'-adenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2',3'-benzylidene-5'-adenosine

There total 1 articles about 2',3'-benzylidene-5'-adenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2',3'-O,O-benzylidene adenosine (3257-69-0) + 4-fluorosulfonylbenzoyl chloride (402-55-1) → 2',3'-benzylidene-5'-adenosine (114958-16-6)

Guidance literature:

With dmap; In N,N-dimethyl-formamide; for 1h;

DOI:10.1021/jm00117a015

Reference yield:

2',3'-benzylidene-5'-adenosine (114958-16-6) → 5'-<4-(phenoxysulfonyl)benzoyl>adenosine (114958-13-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / 18 h / Ambient temperature

2: 50percent aq. TFA / Ambient temperature

With sodium hydride; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/jm00117a015

Reference yield:

2',3'-benzylidene-5'-adenosine (114958-16-6) → 4-[4-(2-Acetylamino-2-carbamoyl-ethyl)-phenoxysulfonyl]-benzoic acid (2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester (114958-14-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / Ambient temperature

2: 80percent aq. HOAc / 100 °C

With sodium hydride; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/jm00117a015

upstream raw materials:

2',3'-O,O-benzylidene adenosine

4-fluorosulfonylbenzoyl chloride

Downstream raw materials:

5'-<4-(phenoxysulfonyl)benzoyl>adenosine

4-[4-(2-Acetylamino-2-carbamoyl-ethyl)-phenoxysulfonyl]-benzoic acid (2R,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl ester

Refernces