(2R)-2-benzyl-3-<<(2-hydroxyethyl)methylamino>carbonyl>propionic acid

Base Information

• Chemical Name: (2R)-2-benzyl-3-<<(2-hydroxyethyl)methylamino>carbonyl>propionic acid
• CAS No.: 122226-21-5
• Molecular Formula: C₁₄H₁₉NO₄
• Molecular Weight: 265.309
• Mol file: 122226-21-5.mol

Synonyms:(2R)-2-benzyl-3-<<(2-hydroxyethyl)methylamino>carbonyl>propionic acid

Chemical Property of (2R)-2-benzyl-3-<<(2-hydroxyethyl)methylamino>carbonyl>propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (2R)-2-benzyl-3-<<(2-hydroxyethyl)methylamino>carbonyl>propionic acid

There total 3 articles about (2R)-2-benzyl-3-<<(2-hydroxyethyl)methylamino>carbonyl>propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl (2R)-2-benzyl-3-<<(2-hydroxyethyl)methylamino>carbonyl>propionate (122226-17-9) → (2R)-2-benzyl-3-<<(2-hydroxyethyl)methylamino>carbonyl>propionic acid (122226-21-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 1h;

DOI:10.1021/jm00169a024

Reference yield:

(3R)-3-Benzyloxycarbonyl-3-phenylmethylpropionic acid (116129-80-7) → (2R)-2-benzyl-3-<<(2-hydroxyethyl)methylamino>carbonyl>propionic acid (122226-21-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate / 1.) CH₂Cl₂, -10 deg C, 3 min, 2a.) -10 deg, 15 min, 2b.) RT, 2 h

2: 100 percent / H₂ / 10percent Pd/C / methanol / 1 h

With 4-methyl-morpholine; hydrogen; isobutyl chloroformate; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00169a024

Reference yield:

→ (2R)-2-benzyl-3-<<(2-hydroxyethyl)methylamino>carbonyl>propionic acid (122226-21-5)

Guidance literature:

upstream raw materials:

benzyl (2R)-2-benzyl-3-<<(2-hydroxyethyl)methylamino>carbonyl>propionate

(3R)-3-Benzyloxycarbonyl-3-phenylmethylpropionic acid

Downstream raw materials:

(R)-2-Benzyl-N¹-[(S)-1-[(1S,2R)-1-cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethyl]-N⁴-(2-hydroxy-ethyl)-N⁴-methyl-succinamide