(-)-(S)-N-[3-(2-diphenyl(methyl)silyl-1,3-dithian-2-yl)propyl]-tetrahydro-5-oxo-2-furancarboxamide

Base Information

Chemical Name:(-)-(S)-N-[3-(2-diphenyl(methyl)silyl-1,3-dithian-2-yl)propyl]-tetrahydro-5-oxo-2-furancarboxamide
CAS No.:1273550-81-4
Molecular Formula:C₂₅H₃₁NO₃S₂Si
Molecular Weight:485.744
Hs Code.:

Synonyms:(-)-(S)-N-[3-(2-diphenyl(methyl)silyl-1,3-dithian-2-yl)propyl]-tetrahydro-5-oxo-2-furancarboxamide

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Chemical Property of (-)-(S)-N-[3-(2-diphenyl(methyl)silyl-1,3-dithian-2-yl)propyl]-tetrahydro-5-oxo-2-furancarboxamide

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Technology Process of (-)-(S)-N-[3-(2-diphenyl(methyl)silyl-1,3-dithian-2-yl)propyl]-tetrahydro-5-oxo-2-furancarboxamide

There total 4 articles about (-)-(S)-N-[3-(2-diphenyl(methyl)silyl-1,3-dithian-2-yl)propyl]-tetrahydro-5-oxo-2-furancarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1273550-80-3
2-(3-aminopropyl)-2-diphenyl(methyl)silyl-1,3-dithiane

: 54848-33-8
(S)-tetrahydro-5-oxo-2-furancarbonyl chloride

: 1273550-81-4
(-)-(S)-N-[3-(2-diphenyl(methyl)silyl-1,3-dithian-2-yl)propyl]-tetrahydro-5-oxo-2-furancarboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 3.66667h; Inert atmosphere; Cooling with ice;
DOI:10.1016/j.tet.2010.12.048

Reference yield:

: C₂₇H₃₁NS₂Si

: 1273550-81-4
(-)-(S)-N-[3-(2-diphenyl(methyl)silyl-1,3-dithian-2-yl)propyl]-tetrahydro-5-oxo-2-furancarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: phenylhydrazine / ethanol / 3.5 h / 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 3.67 h / 20 °C / Inert atmosphere; Cooling with ice

With triethylamine; phenylhydrazine; In tetrahydrofuran; ethanol;
DOI:10.1016/j.tet.2010.12.048

Reference yield:

: 21461-84-7
(2S)-tetrahydro-5-oxofuran-2-carboxylic acid

: 1273550-81-4
(-)-(S)-N-[3-(2-diphenyl(methyl)silyl-1,3-dithian-2-yl)propyl]-tetrahydro-5-oxo-2-furancarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 20 °C / Inert atmosphere; Cooling with ether-dry ice

2: triethylamine / tetrahydrofuran / 3.67 h / 20 °C / Inert atmosphere; Cooling with ice

With oxalyl dichloride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2010.12.048