(-)-(S)-3-hydroxy-1-[3-(2-diphenyl(methyl)silyl-1,3-dithian-2-yl)propyl]-2,6-piperidindione

Base Information

Chemical Name:(-)-(S)-3-hydroxy-1-[3-(2-diphenyl(methyl)silyl-1,3-dithian-2-yl)propyl]-2,6-piperidindione
CAS No.:1273550-82-5
Molecular Formula:C₂₅H₃₁NO₃S₂Si
Molecular Weight:485.744
Hs Code.:

Synonyms:(-)-(S)-3-hydroxy-1-[3-(2-diphenyl(methyl)silyl-1,3-dithian-2-yl)propyl]-2,6-piperidindione

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Chemical Property of (-)-(S)-3-hydroxy-1-[3-(2-diphenyl(methyl)silyl-1,3-dithian-2-yl)propyl]-2,6-piperidindione

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Technology Process of (-)-(S)-3-hydroxy-1-[3-(2-diphenyl(methyl)silyl-1,3-dithian-2-yl)propyl]-2,6-piperidindione

There total 6 articles about (-)-(S)-3-hydroxy-1-[3-(2-diphenyl(methyl)silyl-1,3-dithian-2-yl)propyl]-2,6-piperidindione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1273550-81-4
(-)-(S)-N-[3-(2-diphenyl(methyl)silyl-1,3-dithian-2-yl)propyl]-tetrahydro-5-oxo-2-furancarboxamide

: 1273550-82-5
(-)-(S)-3-hydroxy-1-[3-(2-diphenyl(methyl)silyl-1,3-dithian-2-yl)propyl]-2,6-piperidindione

Guidance literature:: (-)-(S)-N-[3-(2-diphenyl(methyl)silyl-1,3-dithian-2-yl)propyl]-tetrahydro-5-oxo-2-furancarboxamide; With potassium tert-butylate; In tetrahydrofuran; at -40 ℃; for 1.5h; Inert atmosphere; Cooling with acetone-dry ice;

With water; ammonium chloride; In tetrahydrofuran; at -40 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2010.12.048

Reference yield:

: C₂₇H₃₁NS₂Si

: 1273550-82-5
(-)-(S)-3-hydroxy-1-[3-(2-diphenyl(methyl)silyl-1,3-dithian-2-yl)propyl]-2,6-piperidindione

Guidance literature:: Multi-step reaction with 3 steps

1.1: phenylhydrazine / ethanol / 3.5 h / 20 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 3.67 h / 20 °C / Inert atmosphere; Cooling with ice

3.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / -40 °C / Inert atmosphere; Cooling with acetone-dry ice

3.2: -40 °C / Inert atmosphere

With potassium tert-butylate; triethylamine; phenylhydrazine; In tetrahydrofuran; ethanol;
DOI:10.1016/j.tet.2010.12.048

Reference yield:

: 1273550-80-3
2-(3-aminopropyl)-2-diphenyl(methyl)silyl-1,3-dithiane

: 1273550-82-5
(-)-(S)-3-hydroxy-1-[3-(2-diphenyl(methyl)silyl-1,3-dithian-2-yl)propyl]-2,6-piperidindione

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 3.67 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / -40 °C / Inert atmosphere; Cooling with acetone-dry ice

2.2: -40 °C / Inert atmosphere

With potassium tert-butylate; triethylamine; In tetrahydrofuran;
DOI:10.1016/j.tet.2010.12.048