2-(2,5-Dibromothiophen-3-yl)acetic acid

Base Information

• Chemical Name: 2-(2,5-Dibromothiophen-3-yl)acetic acid
• CAS No.: 77014-10-9
• Molecular Formula: C₆H₄Br₂O₂S
• Molecular Weight: 299.971
• European Community (EC) Number: 960-395-9
• Nikkaji Number: J2.838.038K

Synonyms:2-(2,5-dibromothiophen-3-yl)acetic acid;77014-10-9;2,5-Dibromothiophene-3-acetic acid;SCHEMBL365715;CDA01410;F76355;EN300-6477658;Z3304638006

Chemical Property of 2-(2,5-Dibromothiophen-3-yl)acetic acid

Chemical Property:

• Melting Point: 117-118 °C(Solv: benzene (71-43-2))
• Boiling Point: 372.6±37.0 °C(Predicted)
• Density: 2.162±0.06 g/cm3(Predicted)
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 299.82783
• Heavy Atom Count: 11
• Complexity: 165

Purity/Quality:

97% ^*data from raw suppliers

2-(2,5-Dibromo-thiophen-3-yl)aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(SC(=C1CC(=O)O)Br)Br

Technology Process of 2-(2,5-Dibromothiophen-3-yl)acetic acid

There total 1 articles about 2-(2,5-Dibromothiophen-3-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

thiophen-3-yl-acetic acid (6964-21-2) → 2-(2,5-dibromo-thiophen-3-yl)acetic acid (77014-10-9)

Guidance literature:

With bromine; In acetic acid; for 2h; Ambient temperature;

DOI:10.1055/s-1980-29307

Reference yield: 89.0%

4''-hydroxy-1,1':4',1''-terphenyl-4-carbonitrile (160347-76-2) + 2-(2,5-dibromo-thiophen-3-yl)acetic acid (77014-10-9) → 2,5-dibromo-3-{[(4-(4'-cyano)terphenyloxy)carbonyl]methyl}thiophene (1215807-68-3)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1080/15421400903568047

Reference yield: 85.0%

2-(2,5-dibromo-thiophen-3-yl)acetic acid (77014-10-9) + 4-(4'-(10-hydroxydecanyloxy))biphenyl 4-[(S)-2-fluorooctyloxy]benzoate (336110-88-4) → 10-(4-(4'-(4''-[(S)-2-fluorooctyloxy]phenylcarbonyloxy))biphenoxy)decyl (2,5-bromo-3-thienyl)acetate (336110-83-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h;

DOI:10.1021/ma0354492

upstream raw materials:

thiophen-3-yl-acetic acid

Downstream raw materials:

N-<2-(4-Benzyloxy-3-methoxyphenyl)-ethyl>-2,5-dibromothiophene-3-acetamide

N-<2-(3,4-Dimethoxyphenyl)-ethyl>-2,5-dibromothiophene-3-acetamide

10-(4-(4'-(4''-[(S)-2-fluorooctyloxy]phenylcarbonyloxy))biphenoxy)decyl (2,5-bromo-3-thienyl)acetate

7-Benzyloxy-1-(2,5-dibromo-3-thienylmethyl)-6-methoxy-3,4-dihydroisoquinoline hydrochloride

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