1-[(2,5-Dibromothiophen-3-yl)methyl]-6-methoxy-7-phenylmethoxy-3,4-dihydroisoquinoline;hydrochloride

Base Information

Chemical Name:1-[(2,5-Dibromothiophen-3-yl)methyl]-6-methoxy-7-phenylmethoxy-3,4-dihydroisoquinoline;hydrochloride
CAS No.:77014-14-3
Molecular Formula:C22H19Br2NO2S
Molecular Weight:521.2648
Hs Code.:
DSSTox Substance ID:DTXSID30998300
NSC Number:345773

Synonyms:77014-14-3;DTXSID30998300;NSC345773;NSC-345773;7-(Benzyloxy)-1-[(2,5-dibromothiophen-3-yl)methyl]-6-methoxy-3,4-dihydroisoquinoline--hydrogen chloride (1/1)

Suppliers and Price of 1-[(2,5-Dibromothiophen-3-yl)methyl]-6-methoxy-7-phenylmethoxy-3,4-dihydroisoquinoline;hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 1-[(2,5-Dibromothiophen-3-yl)methyl]-6-methoxy-7-phenylmethoxy-3,4-dihydroisoquinoline;hydrochloride

Chemical Property:

Vapor Pressure:2.34E-13mmHg at 25°C
Boiling Point:591.9°Cat760mmHg
Flash Point:311.7°C
Density:1.58g/cm³
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:556.92495
Heavy Atom Count:29
Complexity:543

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)CCN=C2CC3=C(SC(=C3)Br)Br)OCC4=CC=CC=C4.Cl

Technology Process of 1-[(2,5-Dibromothiophen-3-yl)methyl]-6-methoxy-7-phenylmethoxy-3,4-dihydroisoquinoline;hydrochloride

There total 3 articles about 1-[(2,5-Dibromothiophen-3-yl)methyl]-6-methoxy-7-phenylmethoxy-3,4-dihydroisoquinoline;hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 77014-12-1
N-<2-(4-Benzyloxy-3-methoxyphenyl)-ethyl>-2,5-dibromothiophene-3-acetamide

: 77014-14-3
7-Benzyloxy-1-(2,5-dibromo-3-thienylmethyl)-6-methoxy-3,4-dihydroisoquinoline hydrochloride

Guidance literature:: With phosphorus pentachloride; In chloroform; for 5h; Ambient temperature;
DOI:10.1055/s-1980-29307

Reference yield:

: 6964-21-2
thiophen-3-yl-acetic acid

: 77014-14-3
7-Benzyloxy-1-(2,5-dibromo-3-thienylmethyl)-6-methoxy-3,4-dihydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / bromine / acetic acid / 2 h / Ambient temperature

2: 65 percent / 2 h / Heating

3: 87 percent / PCl₅ / CHCl₃ / 10 h / Ambient temperature

With phosphorus pentachloride; bromine; In chloroform; acetic acid;

Reference yield:

: 77014-10-9
2-(2,5-dibromo-thiophen-3-yl)acetic acid

: 77014-14-3
7-Benzyloxy-1-(2,5-dibromo-3-thienylmethyl)-6-methoxy-3,4-dihydroisoquinoline hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / 2 h / Heating

2: 87 percent / PCl₅ / CHCl₃ / 10 h / Ambient temperature

With phosphorus pentachloride; In chloroform;