4-(4-fluorophenyl)-1,2-dihydro-2-methyl-1-oxo-3-pyrido[4,3-c]pyridine carboxylic acid

Base Information

Chemical Name:4-(4-fluorophenyl)-1,2-dihydro-2-methyl-1-oxo-3-pyrido[4,3-c]pyridine carboxylic acid
CAS No.:168542-06-1
Molecular Formula:C₁₆H₁₁FN₂O₃
Molecular Weight:298.273
Hs Code.:

Synonyms:4-(4-fluorophenyl)-1,2-dihydro-2-methyl-1-oxo-3-pyrido[4,3-c]pyridine carboxylic acid

Suppliers and Price of 4-(4-fluorophenyl)-1,2-dihydro-2-methyl-1-oxo-3-pyrido[4,3-c]pyridine carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-(4-fluorophenyl)-1,2-dihydro-2-methyl-1-oxo-3-pyrido[4,3-c]pyridine carboxylic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-(4-fluorophenyl)-1,2-dihydro-2-methyl-1-oxo-3-pyrido[4,3-c]pyridine carboxylic acid

There total 7 articles about 4-(4-fluorophenyl)-1,2-dihydro-2-methyl-1-oxo-3-pyrido[4,3-c]pyridine carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 168542-11-8
4-(4-fluorophenyl)-1,2-dihydro-2-methyl-1-oxo-3-pyrido[4,3-c]pyridinecarboxylic acid ethyl ester

: 168542-06-1
4-(4-fluorophenyl)-1,2-dihydro-2-methyl-1-oxo-3-pyrido[4,3-c]pyridine carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; for 2h; Heating;
DOI:10.1248/cpb.45.1642

Reference yield:

: 4664-08-8
cinchomeronic anhydride

: 168542-06-1
4-(4-fluorophenyl)-1,2-dihydro-2-methyl-1-oxo-3-pyrido[4,3-c]pyridine carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 11 percent / AlCl₃ / 3 h / Heating

2: SOCl₂, DMF / tetrahydrofuran / 1 h / Heating

3: Et₃N / tetrahydrofuran / 14 h / Ambient temperature

4: 38 percent / DBU / toluene / 4.5 h / Heating

5: 95 percent / 1N aq. NaOH / methanol; tetrahydrofuran / 2 h / Heating

With sodium hydroxide; aluminium trichloride; thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; toluene;
DOI:10.1248/cpb.45.1642

Reference yield:

: 462-06-6
fluorobenzene

: 168542-06-1
4-(4-fluorophenyl)-1,2-dihydro-2-methyl-1-oxo-3-pyrido[4,3-c]pyridine carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 11 percent / AlCl₃ / 3 h / Heating

2: SOCl₂, DMF / tetrahydrofuran / 1 h / Heating

3: Et₃N / tetrahydrofuran / 14 h / Ambient temperature

4: 38 percent / DBU / toluene / 4.5 h / Heating

5: 95 percent / 1N aq. NaOH / methanol; tetrahydrofuran / 2 h / Heating

With sodium hydroxide; aluminium trichloride; thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; toluene;
DOI:10.1248/cpb.45.1642