2-(3,5-bis-trifluoromethyl-phenyl)-N-[1-ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methyl-isobutyramide

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Chemical Name:2-(3,5-bis-trifluoromethyl-phenyl)-N-[1-ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methyl-isobutyramide
CAS No.:1340591-74-3
Molecular Formula:C₂₈H₂₅F₇N₄O
Molecular Weight:566.522
Hs Code.:

Synonyms:2-(3,5-bis-trifluoromethyl-phenyl)-N-[1-ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methyl-isobutyramide

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Chemical Property of 2-(3,5-bis-trifluoromethyl-phenyl)-N-[1-ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methyl-isobutyramide

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Technology Process of 2-(3,5-bis-trifluoromethyl-phenyl)-N-[1-ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methyl-isobutyramide

There total 7 articles about 2-(3,5-bis-trifluoromethyl-phenyl)-N-[1-ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methyl-isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 289686-69-7
2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl chloride

: 1340592-15-5
[1-ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-methyl-amine

: 1340591-74-3
2-(3,5-bis-trifluoromethyl-phenyl)-N-[1-ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methyl-isobutyramide

Guidance literature:: With triethylamine; In dichloromethane; at 35 ℃;

Reference yield:

: 26823-99-4
[[(1-ethyl-5-pyrazolyl)amino]methylene]malonic acid diethyl ester

: 1340591-74-3
2-(3,5-bis-trifluoromethyl-phenyl)-N-[1-ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methyl-isobutyramide

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / 8 h / 135 °C

1.2: 0 °C / pH 7

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 15 h / 70 °C / Inert atmosphere

3.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 3 h / 50 °C

3.2: pH 3

4.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 7 h / 60 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

5.2: 0 - 20 °C

6.1: triethylamine / dichloromethane / 35 °C

With diphenyl phosphoryl azide; water; sodium hydride; sodium carbonate; triethylamine; sodium hydroxide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 2.1: Suzuki Coupling;

Reference yield:

: 30720-25-3
ethyl 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

: 1340591-74-3
2-(3,5-bis-trifluoromethyl-phenyl)-N-[1-ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methyl-isobutyramide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 15 h / 70 °C / Inert atmosphere

2.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 3 h / 50 °C

2.2: pH 3

3.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 7 h / 60 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

4.2: 0 - 20 °C

5.1: triethylamine / dichloromethane / 35 °C

With diphenyl phosphoryl azide; water; sodium hydride; sodium carbonate; triethylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1.1: Suzuki Coupling;