METHYL 4-[(3-FLUOROBENZYL)OXY]BENZENECARBOXYLATE

Base Information

• Chemical Name: METHYL 4-[(3-FLUOROBENZYL)OXY]BENZENECARBOXYLATE
• CAS No.: 454473-78-0
• Molecular Formula: C₁₅H₁₃FO₃
• Molecular Weight: 260.265
• Hs Code.: 2918290090
• Mol file: 454473-78-0.mol

Synonyms:methyl 4-[(3-fluorobenzyl)oxy]benzoate

Chemical Property of METHYL 4-[(3-FLUOROBENZYL)OXY]BENZENECARBOXYLATE

Chemical Property:

• Melting Point: 71-73°C

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 4-[(3-fluorobenzyl)oxy]benzenecarboxylate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of METHYL 4-[(3-FLUOROBENZYL)OXY]BENZENECARBOXYLATE

There total 1 articles about METHYL 4-[(3-FLUOROBENZYL)OXY]BENZENECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) + 1-(Bromomethyl)-3-fluorobenzene (456-41-7) → methyl 4-[(3-fluorobenzyl)oxy]benzoate (454473-78-0)

Guidance literature:

With potassium carbonate; In acetone; at 65 - 80 ℃; for 5h;

DOI:10.1039/c5md00092k

Reference yield: 79.0%

methyl 4-[(3-fluorobenzyl)oxy]benzoate (454473-78-0) → 4-(3-fluorobenzyloxy)benzoic acid (405-85-6)

Guidance literature:

methyl 4-[(3-fluorobenzyl)oxy]benzoate; With water; sodium hydroxide; In methanol; at 75 ℃; for 2h;

With hydrogenchloride; In water; pH=5;

DOI:10.1039/c5md00092k

Reference yield:

methyl 4-[(3-fluorobenzyl)oxy]benzoate (454473-78-0) → C14H10ClFO2 (1160250-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / methanol / 2 h / 75 °C

1.2: pH 5

2.1: pyridine; thionyl chloride / toluene / 6 h / 72 °C

With pyridine; thionyl chloride; water; sodium hydroxide; In methanol; toluene;

DOI:10.1039/c5md00092k

upstream raw materials:

methyl 4-hydroxylbenzoate

1-(Bromomethyl)-3-fluorobenzene

Downstream raw materials:

4-(3-fluorobenzyloxy)benzoic acid

C₁₄H₁₀ClFO₂