4-(3-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)benzenesulfonic acid

Base Information

Chemical Name:4-(3-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)benzenesulfonic acid
CAS No.:1179329-09-9
Molecular Formula:C₂₇H₂₂F₃N₅O₆S
Molecular Weight:601.563
Hs Code.:

Synonyms:4-(3-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)benzenesulfonic acid

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Chemical Property of 4-(3-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)benzenesulfonic acid

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Technology Process of 4-(3-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)benzenesulfonic acid

There total 8 articles about 4-(3-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)benzenesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1179329-74-8
4-(3-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)benzenesulfonyl chloride

: 1179329-09-9
4-(3-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)benzenesulfonic acid

Guidance literature:: With sodium hydroxide; In acetonitrile; at 20 ℃; for 48h;

Reference yield:

: 143782-20-1
4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

: 1179329-09-9
4-(3-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)benzenesulfonic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetonitrile / 5 h / 20 °C

2.1: caesium carbonate; Benzophenone imine / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 6 h / 95 °C / Inert atmosphere

2.2: 0.17 h / 20 °C

3.1: tetrahydrofuran / 20 °C

4.1: sodium hydroxide / acetonitrile / 48 h / 20 °C

With Benzophenone imine; potassium carbonate; caesium carbonate; sodium hydroxide; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; acetonitrile;

Reference yield:

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

: 1179329-09-9
4-(3-{2-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-ylmethyl]phenyl}ureido)benzenesulfonic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene; acetonitrile / 70 °C

1.2: 20 °C

1.3: 1 h / 70 °C

2.1: potassium carbonate / acetonitrile / 5 h / 20 °C

3.1: caesium carbonate; Benzophenone imine / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 6 h / 95 °C / Inert atmosphere

3.2: 0.17 h / 20 °C

4.1: tetrahydrofuran / 20 °C

5.1: sodium hydroxide / acetonitrile / 48 h / 20 °C

With Benzophenone imine; potassium carbonate; caesium carbonate; sodium hydroxide; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; toluene; acetonitrile;