2-(3-carboxyphenyl)-7-methoxy-4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran

Base Information

Chemical Name:2-(3-carboxyphenyl)-7-methoxy-4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran
CAS No.:934969-43-4
Molecular Formula:C₂₈H₂₇NO₆
Molecular Weight:473.525
Hs Code.:

Synonyms:2-(3-carboxyphenyl)-7-methoxy-4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran

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Chemical Property of 2-(3-carboxyphenyl)-7-methoxy-4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran

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Technology Process of 2-(3-carboxyphenyl)-7-methoxy-4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran

There total 6 articles about 2-(3-carboxyphenyl)-7-methoxy-4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 934969-42-3
3-[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-7-methoxy-benzofuran-2-yl]-benzonitrile

: 934969-43-4
2-(3-carboxyphenyl)-7-methoxy-4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran

Guidance literature:: With sodium hydroxide; In ethylene glycol; at 160 ℃; for 36h;
DOI:10.1016/j.bmcl.2006.12.094

Reference yield:

: 934969-40-1
2-(3-cyanophenyl)-7-methoxybenzofuran

: 934969-43-4
2-(3-carboxyphenyl)-7-methoxy-4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / (Cl₂PO)2O / 24 h / 20 °C

2: NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C

3: 95 percent / aq. NaOH / ethane-1,2-diol / 36 h / 160 °C

With sodium hydroxide; pyrophosphoryl chloride; sodium tris(acetoxy)borohydride; In ethylene glycol; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2006.12.094

Reference yield:

: 934969-41-2
2-(3-cyanophenyl)-4-formyl-7-methoxybenzofuran

: 934969-43-4
2-(3-carboxyphenyl)-7-methoxy-4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C

2: 95 percent / aq. NaOH / ethane-1,2-diol / 36 h / 160 °C

With sodium hydroxide; sodium tris(acetoxy)borohydride; In ethylene glycol; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2006.12.094