934969-41-2

Upstream product

• 934969-40-1 2-(3-cyanophenyl)-7-methoxybenzofuran 
• 93-61-8 N-methyl-N-phenylformamide 
• 28188-41-2 m-(bromomethyl)benzonitrile 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 

Downstream Products

• 934969-43-4 2-(3-carboxyphenyl)-7-methoxy-4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran 
• 934969-42-3 3-[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)-7-methoxy-benzofuran-2-yl]-benzonitrile 

Relevant academic research and scientific papers

Novel 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran derivatives as selective α2C-adrenergic receptor antagonists

The synthesis of a series of 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methyl-2-arylbenzofuran and 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran-2-carboxamide derivatives as novel α2C-adrenergic receptor antagonists are described. Their affinity at three different human α2-adrenergic receptors is reported, and some of these compounds exhibited high affinity for the α2C-adrenergic receptor with high subtype selectivity. Among them, compound 10e has been found to show the anti-l-dopa-induced dyskinetic activity in marmosets. The structure-activity relationship of these compounds is also discussed.