N₁-methyl-N₁-(2-morpholinoethyl)-N₃-(4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)isophthalamide 2,2,2-trifluoroacetate

Base Information

• Chemical Name: N₁-methyl-N₁-(2-morpholinoethyl)-N₃-(4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)isophthalamide 2,2,2-trifluoroacetate
• CAS No.: 1354826-21-3
• Molecular Formula: C₂HF₃O₂*C₃₆H₃₈F₃N₅O₄
• Molecular Weight: 775.748

Synonyms:N₁-methyl-N₁-(2-morpholinoethyl)-N₃-(4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)isophthalamide 2,2,2-trifluoroacetate

Chemical Property of N₁-methyl-N₁-(2-morpholinoethyl)-N₃-(4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)isophthalamide 2,2,2-trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-methyl-N₁-(2-morpholinoethyl)-N₃-(4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)isophthalamide 2,2,2-trifluoroacetate

There total 17 articles about N₁-methyl-N₁-(2-morpholinoethyl)-N₃-(4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)isophthalamide 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

N1-methyl-N1-(2-morpholinoethyl)-N3-(2-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indole-2-carbonyl)-4-(piperidin-1-yl)phenyl)isophthalamide (1354826-31-5) + trifluoroacetic acid (76-05-1) → N1-methyl-N1-(2-morpholinoethyl)-N3-(4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)isophthalamide 2,2,2-trifluoroacetate (1354826-21-3)

Guidance literature:

N₁-methyl-N₁-(2-morpholinoethyl)-N₃-(2-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indole-2-carbonyl)-4-(piperidin-1-yl)phenyl)isophthalamide; With tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol; at 85 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

methyl-(2-morpholin-4-yl-ethyl)-amine (41239-40-1) → N1-methyl-N1-(2-morpholinoethyl)-N3-(4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)isophthalamide 2,2,2-trifluoroacetate (1354826-21-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 25 °C

2.2: pH 2 - 3

3.1: oxalyl dichloride / N,N-dimethyl-formamide / 2 h / 20 °C

4.1: pyridine / dichloromethane / 2 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran; methanol / 85 °C

With pyridine; oxalyl dichloride; lithium hydroxide monohydrate; tetrabutyl ammonium fluoride; water; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

5-(piperidin-1-yl)-2-nitrobenzaldehyde (113259-79-3) → N1-methyl-N1-(2-morpholinoethyl)-N3-(4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)isophthalamide 2,2,2-trifluoroacetate (1354826-21-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -80 - 0 °C / Inert atmosphere

1.2: 4.5 h / -80 - 20 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -80 °C / Inert atmosphere

2.2: 1 h / -80 - -20 °C

3.1: hydrogen / palladium on activated charcoal / methanol / 10 °C / Inert atmosphere

4.1: pyridine / dichloromethane / 2 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran; methanol / 85 °C

With pyridine; n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;

upstream raw materials:

5-(piperidin-1-yl)-2-nitrobenzaldehyde

5-chloro-2-nitrobenzaldehyde ethylene acetal

methyl-(2-morpholin-4-yl-ethyl)-amine

N₁-methyl-N₁-(2-morpholinoethyl)-N₃-(2-(1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indole-2-carbonyl)-4-(piperidin-1-yl)phenyl)isophthalamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1354826-21-3 N₁-methyl-N₁-(2-morpholinoethyl)-N₃-(4-(piperidin-1-yl)-2-(6-(trifluoromethyl)-1H-indole-2-carbonyl)phenyl)isophthalamide 2,2,2-trifluoroacetate

Send

Send

Metric Ton KG G Pound L ML

Send

Send