(3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-((R)-1-hydroxy-ethyl)-4-phenylsulfanyl-azetidin-2-one

Base Information

Chemical Name:(3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-((R)-1-hydroxy-ethyl)-4-phenylsulfanyl-azetidin-2-one
CAS No.:85281-79-4
Molecular Formula:C₁₇H₂₇NO₂SSi
Molecular Weight:337.558
Hs Code.:

Synonyms:(3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-((R)-1-hydroxy-ethyl)-4-phenylsulfanyl-azetidin-2-one

Suppliers and Price of (3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-((R)-1-hydroxy-ethyl)-4-phenylsulfanyl-azetidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-((R)-1-hydroxy-ethyl)-4-phenylsulfanyl-azetidin-2-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-((R)-1-hydroxy-ethyl)-4-phenylsulfanyl-azetidin-2-one

There total 8 articles about (3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-((R)-1-hydroxy-ethyl)-4-phenylsulfanyl-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 85254-18-8
(3S,4R)-3-Acetyl-1-(tert-butyl-dimethyl-silanyl)-4-phenylsulfanyl-azetidin-2-one

: 85281-80-7
(3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-((S)-1-hydroxy-ethyl)-4-phenylsulfanyl-azetidin-2-one

: 85281-79-4
(3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-((R)-1-hydroxy-ethyl)-4-phenylsulfanyl-azetidin-2-one

Guidance literature:: With sodium tetrahydroborate; In methanol; at -78 ℃;
DOI:10.1039/c39820001324

Reference yield:

: 85270-00-4
(4R)-4-phenylthio-2-azetidinone

: 85281-79-4
(3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-((R)-1-hydroxy-ethyl)-4-phenylsulfanyl-azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide

2: iPr₂NLi

3: 86 percent / Collins reagent / CH₂Cl₂

4: 23 percent / NaBH₄ / methanol / -78 °C

With 1H-imidazole; sodium tetrahydroborate; Collins oxidation agent; lithium diisopropyl amide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c39820001324

Reference yield:

: 85281-77-2
N-(tert-butyldimethylsilyl)-4-thiophenyl-2-azetidinone

: 85281-79-4
(3S,4R)-1-(tert-Butyl-dimethyl-silanyl)-3-((R)-1-hydroxy-ethyl)-4-phenylsulfanyl-azetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: iPr₂NLi

2: 86 percent / Collins reagent / CH₂Cl₂

3: 23 percent / NaBH₄ / methanol / -78 °C

With sodium tetrahydroborate; Collins oxidation agent; lithium diisopropyl amide; In methanol; dichloromethane;
DOI:10.1039/c39820001324