3-[4-(4-p-methoxyphenylpiperazino)butyl]-5-cyanoindole

Base Information

Chemical Name:3-[4-(4-p-methoxyphenylpiperazino)butyl]-5-cyanoindole
CAS No.:143612-66-2
Molecular Formula:C₂₄H₂₈N₄O
Molecular Weight:388.513
Hs Code.:

Synonyms:3-[4-(4-p-methoxyphenylpiperazino)butyl]-5-cyanoindole

Suppliers and Price of 3-[4-(4-p-methoxyphenylpiperazino)butyl]-5-cyanoindole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of 3-[4-(4-p-methoxyphenylpiperazino)butyl]-5-cyanoindole

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of 3-[4-(4-p-methoxyphenylpiperazino)butyl]-5-cyanoindole

There total 4 articles about 3-[4-(4-p-methoxyphenylpiperazino)butyl]-5-cyanoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-[4-(N,N-bis(2-chloroethyl)amino)butyl]-5-cyanoindole

: 104-94-9
4-methoxy-aniline

: 334-22-5
N,N-bis(chloro-2-ethyl)amine

: 143612-79-7
3-(4-chlorobutyl)-5-cyanoindole

: 143612-66-2
3-[4-(4-p-methoxyphenylpiperazino)butyl]-5-cyanoindole

Guidance literature:: In acetonitrile;

Reference yield:

: 15861-24-2,142396-06-3
1H-indole-5-carbonitrile

: 143612-66-2
3-[4-(4-p-methoxyphenylpiperazino)butyl]-5-cyanoindole

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / isobutyl-AlCl₂ / CH₂Cl₂ / 15 - 30 °C

2: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h

3: K₂CO₃; KI / dimethylformamide / Heating

With isobutylaluminum dichloride; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; potassium iodide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm040793q

Reference yield:

: 276863-95-7
3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile

: 143612-66-2
3-[4-(4-p-methoxyphenylpiperazino)butyl]-5-cyanoindole

Guidance literature:: Multi-step reaction with 2 steps

1: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h

2: K₂CO₃; KI / dimethylformamide / Heating

With potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm040793q